Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: First in vivo evidence

被引：12

作者：

Cerdeira, Ana Sofia ^{[1
,2
]}

Kandzija, Neva ^{[1
]}

Pargmae, Pille ^{[2
]}

Cooke, William ^{[1
,2
]}

James, Tim ^{[3
]}

Redman, Christopher ^{[1
]}

Vatish, Manu ^{[1
,2
]}

机构：

[1] Univ Oxford, Nuffield Dept Womens Hlth & Reprod Res, John Radcliffe Oxford Univ Hosp, Womens Ctr, Level 3, Oxford OX3 9DU, England

[2] John Radcliffe Oxford Univ Hosp, Dept Obstet & Gynecol, Womens Ctr, Oxford OX3 9DU, England

[3] John Radcliffe Oxford Univ Hosp, Dept Biochem, Oxford OX3 9DU, England

来源：

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH | 2019年 / 16卷

关键词：

Placenta; Pregnancy; sFlt-1; Uterine vein; Preeclampsia; GROWTH-FACTOR RECEPTOR-1; EXCESS;

D O I：

10.1016/j.preghy.2019.03.013

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Circulating sFlt-1 increases significantly in pregnancy compared to the non-pregnant state and even more so in the event of preeclampsia. We set out to determine if circulating sFlt-1 is placentally derived in normal pregnancy. Paired uterine and peripheral vein samples were collected at time of caesarean section. A follow up peripheral sample was collected in the postpartum period. There was a significant sFlt-1 gradient between uterine and peripheral veins. sFlt-1 levels dropped significantly when the placenta has been removed, i.e. postnatally. This is in keeping with the placenta being the main site of sFlt-1 production in normal pregnancies.

引用

页码：145 / 147

页数：3

共 7 条

[1] Evidence supporting that the excess of the sVEGFR-1 concentration in maternal plasma in preeclampsia has a uterine origin [J].