Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: First in vivo evidence

被引：12
作者：
Cerdeira, Ana Sofia [1 ,2 ]
Kandzija, Neva [1 ]
Pargmae, Pille [2 ]
Cooke, William [1 ,2 ]
James, Tim [3 ]
Redman, Christopher [1 ]
Vatish, Manu [1 ,2 ]
机构：
[1] Univ Oxford, Nuffield Dept Womens Hlth & Reprod Res, John Radcliffe Oxford Univ Hosp, Womens Ctr, Level 3, Oxford OX3 9DU, England
[2] John Radcliffe Oxford Univ Hosp, Dept Obstet & Gynecol, Womens Ctr, Oxford OX3 9DU, England
[3] John Radcliffe Oxford Univ Hosp, Dept Biochem, Oxford OX3 9DU, England
来源：
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH | 2019年 / 16卷
关键词：
Placenta; Pregnancy; sFlt-1; Uterine vein; Preeclampsia; GROWTH-FACTOR RECEPTOR-1; EXCESS;
D O I：
10.1016/j.preghy.2019.03.013
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Circulating sFlt-1 increases significantly in pregnancy compared to the non-pregnant state and even more so in the event of preeclampsia. We set out to determine if circulating sFlt-1 is placentally derived in normal pregnancy. Paired uterine and peripheral vein samples were collected at time of caesarean section. A follow up peripheral sample was collected in the postpartum period. There was a significant sFlt-1 gradient between uterine and peripheral veins. sFlt-1 levels dropped significantly when the placenta has been removed, i.e. postnatally. This is in keeping with the placenta being the main site of sFlt-1 production in normal pregnancies.
引用
收藏
页码：145 / 147
页数：3
相关论文
共 7 条
  • [1] Evidence supporting that the excess of the sVEGFR-1 concentration in maternal plasma in preeclampsia has a uterine origin
    Bujold, E
    Romero, R
    Chaiworapongsa, T
    Kim, YM
    Kim, GJ
    Kim, MR
    Espinoza, J
    Gonçalves, LF
    Edwin, S
    Mazor, M
    [J]. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2005, 18 (01) : 9 - 16
  • [2] In vivo uteroplacental release of placental growth factor and soluble Fms-like tyrosine kinase-1 in normal and preeclamptic pregnancies
    Holme, Ane M.
    Roland, Marie C. P.
    Henriksen, Tore
    Michelsen, Trond M.
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2016, 215 (06)
  • [3] Circulating angiogenic factors and the risk of preeclampsia
    Levine, RJ
    Maynard, SE
    Qian, C
    Lim, KH
    England, LJ
    Yu, KF
    Schisterman, EF
    Thadhani, R
    Sachs, BP
    Epstein, FH
    Sibai, BM
    Sukhatme, VP
    Karumanchi, SA
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (07) : 672 - 683
  • [4] Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfimction, hypertension, and proteinuria in preeclampsia
    Maynard, SE
    Min, JY
    Merchan, J
    Lim, KH
    Li, JY
    Mondal, S
    Libermann, TA
    Morgan, LP
    Sellke, FW
    Stillman, IE
    Epstein, FH
    Sukhatme, VP
    Karumanchi, SA
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (05) : 649 - 658
  • [5] Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFit-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women
    Rajakumar, A
    Michael, HM
    Rajakumar, PA
    Shibata, E
    Hubel, CA
    Karumanchi, SA
    Thadhani, R
    Wolf, M
    Harger, G
    Markovic, N
    [J]. PLACENTA, 2005, 26 (07) : 563 - 573
  • [6] A novel human-specific soluble vascular endothelial growth factor receptor 1 - Cell type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia
    Sela, Shay
    Itin, Ahuva
    Natanson-Yaron, Shira
    Greenfield, Caryn
    Goldman-Wohl, Debra
    Yagel, Simcha
    Keshet, Eli
    [J]. CIRCULATION RESEARCH, 2008, 102 (12) : 1566 - 1574
  • [7] 2012, PLACENTA, V33, P224, DOI DOI 10.1016/J.PLACENTA.2012.01.001
1