The influence of angiotensin-(1-7) Mas receptor agonist (AVE 0991) on mitochondrial proteome in kidneys of apoE knockout mice

被引：19
作者：
Suski, Maciej [1 ]
Olszanecki, Rafal [1 ]
Stachowicz, Aneta [1 ]
Madej, Jozef [1 ]
Bujak-Gizycka, Beata [1 ]
Okon, Krzysztof [2 ]
Korbut, Ryszard [1 ]
机构：
[1] Jagiellonian Univ, Coll Med, Chair Pharmacol, PL-31531 Krakow, Poland
[2] Jagiellonian Univ, Coll Med, Chair Pathomorphol, PL-31531 Krakow, Poland
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2013年 / 1834卷 / 12期
关键词：
Kidney; Mitochondrion; Apolipoprotein E; Angiotensin (1-7); Proteomics; MIGRATION INHIBITORY FACTOR; D-DOPACHROME TAUTOMERASE; CARBONIC-ANHYDRASES; LIVER-MITOCHONDRIA; SYSTEM FOCUS; DISEASE; SUPEROXIDE; METABOLISM; APOPTOSIS; HYPERTENSION;
D O I：
10.1016/j.bbapap.2013.08.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Excessive action of angiotensin H on mitochondria has been shown to play an important role in mitochondrial dysfunction, a common feature of atherogenesis and kidney injury. Angiotensin-(1-7)/Mas receptor axis constitutes a countermeasure to the detrimental effects of angiotensin H on AT1 receptors. The aim of the study was to assess the effects of angiotensin-(1-7) peptidomimetic AVE0991 on the kidney mitochondrial proteome in widely used animal model of atherosclerosis (apoE(-/-) mice). Proteins changed in apoE(-/-) mice belonged to the groups of antioxidant enzymes, apoptosis regulators, inflammatory factors and metabolic enzymes. Importantly, AVE0991 partially reversed atherosclerosis-related changes in apoE(-/-) mice. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：2463 / 2469
页数：7
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