Relationship between sympathetic nerve activity and aortic wave reflection characteristics in postmenopausal women

被引:0
作者
Hart, Emma C. [1 ]
Charkoudian, Nisha [2 ]
Joyner, Michael J. [1 ]
Barnes, Jill N. [1 ]
Curry, Timothy B. [1 ]
Casey, Darren P. [1 ]
机构
[1] Mayo Clin, Dept Anesthesiol, Rochester, MN USA
[2] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA
来源
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2013年 / 20卷 / 09期
基金
美国国家卫生研究院;
关键词
Aortic pressure; Sympathetic nerve activity; Menopause; Women; Pressure wave reflection; ARTERIAL-PRESSURE REGULATION; AGE-RELATED-CHANGES; TOTAL BLOOD-VOLUME; CARDIAC-OUTPUT; CARDIOVASCULAR EVENTS; AUGMENTATION INDEX; VASCULAR-DISEASE; STROKE VOLUME; HEALTHY-MEN; GENDER;
D O I
10.1097/gme.0b013e3182843b59
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: Aortic wave reflection characteristics, such as augmentation index, are positively related to muscle sympathetic nerve activity in young men. In young women, there is an inverse relationship. We investigated whether this inverse relationship persisted in postmenopausal women. Methods: Muscle sympathetic nerve activity (peroneal microneurography) and arterial pressure (brachial catheter) were measured in 16 postmenopausal women (mean [SEM] age, 60 [2] y). Aortic blood pressure and wave form characteristics were synthesized from radial arterial pressure waves (applanation tonometry). Specifically, augmentation index, wave reflection amplitude, and estimated wasted left ventricular energy were calculated. These data were compared with our previously published work from an identical protocol in 23 young women (mean [SEM] age, 25 [1] y). Results: Tonic sympathetic activity was higher in postmenopausal women than in young women (64 [3] vs 24 [4] bursts/100 heartbeats). All indices of aortic wave reflection were higher in postmenopausal women than in young women (P < 0.05). Baseline sympathetic activity was inversely related to augmentation index (r = -0.63, P < 0.05), augmented pressure (r = -0.62, P < 0.05), and wasted left ventricular energy (r = -0.61, P < 0.05) in young women. Conversely, baseline sympathetic activity was positively related to augmentation index (r = 0.63, P = 0.09), augmented pressure (r = 0.69, P < 0.05), and wasted left ventricular energy (r = 0.79, P < 0.05) in postmenopausal women. Conclusions: High levels of sympathetic activity are associated with higher indices of aortic wave reflection in postmenopausal women. Consequently, postmenopausal women with high sympathetic activity may be more at risk for developing cardiovascular diseases or experiencing adverse cardiovascular system-related events.
引用
收藏
页码:960 / 966
页数:7
相关论文
共 45 条
[1]   Sedentary aging increases resting and exercise-induced intramuscular free radical formation [J].
Bailey, Damian M. ;
McEneny, Jane ;
Mathieu-Costello, Odile ;
Henry, Robert R. ;
James, Philip E. ;
McCord, Joe M. ;
Pietri, Sylvia ;
Young, Ian S. ;
Richardson, Russell S. .
JOURNAL OF APPLIED PHYSIOLOGY, 2010, 109 (02) :449-456
[2]   Pulse contour cardiac output derived from non-invasive arterial pressure in cardiovascular disease [J].
Bogert, L. W. J. ;
Wesseling, K. H. ;
Schraa, O. ;
Van Lieshout, E. J. ;
de Mol, B. A. J. M. ;
van Goudoever, J. ;
Westerhof, B. E. ;
van Lieshout, J. J. .
ANAESTHESIA, 2010, 65 (11) :1119-1125
[3]   PREVALENCE OF HYPERTENSION IN THE US ADULT-POPULATION - RESULTS FROM THE 3RD NATIONAL-HEALTH AND NUTRITION EXAMINATION SURVEY, 1988-1991 [J].
BURT, VL ;
WHELTON, P ;
ROCCELLA, EJ ;
BROWN, C ;
CUTLER, JA ;
HIGGINS, M ;
HORAN, MJ ;
LABARTHE, D .
HYPERTENSION, 1995, 25 (03) :305-313
[4]   Effect of resistance training on arterial wave reflection and brachial artery reactivity in normotensive postmenopausal women [J].
Casey, Darren P. ;
Pierce, Gary L. ;
Howe, Kathy S. ;
Mering, Mark C. ;
Braith, Randy W. .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2007, 100 (04) :403-408
[5]   Relationship Between Muscle Sympathetic Nerve Activity and Aortic Wave Reflection Characteristics in Young Men and Women [J].
Casey, Darren P. ;
Curry, Timothy B. ;
Joyner, Michael J. ;
Charkoudian, Nisha ;
Hart, Emma C. .
HYPERTENSION, 2011, 57 (03) :421-U161
[6]   Balance between cardiac output and sympathetic nerve activity in resting humans: role in arterial pressure regulation [J].
Charkoudian, N ;
Joyner, MJ ;
Johnson, CP ;
Eisenach, JH ;
Dietz, NA ;
Wallin, BG .
JOURNAL OF PHYSIOLOGY-LONDON, 2005, 568 (01) :315-321
[7]  
Chen CH, 1997, CIRCULATION, V95, P1827
[8]   TOTAL BLOOD-VOLUME IN HEALTHY-YOUNG AND OLDER MEN [J].
DAVY, KP ;
SEALS, DR .
JOURNAL OF APPLIED PHYSIOLOGY, 1994, 76 (05) :2059-2062
[9]   Aging and forearm postjunctional α-adrenergic vasoconstriction in healthy men [J].
Dinenno, FA ;
Dietz, NM ;
Joyner, MJ .
CIRCULATION, 2002, 106 (11) :1349-1354
[10]   Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase [J].
Donato, Anthony J. ;
Gano, Lindsey B. ;
Eskurza, Iratxe ;
Silver, Annemarie E. ;
Gates, Phillip E. ;
Jablonski, Kristen ;
Seals, Douglas R. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2009, 297 (01) :H425-H432