Restricted expression of mouse GCMa/Gcm1 in kidney and thymus

被引：31

作者：

Hashemolhosseini, S

Hadjihannas, M

Stolt, CC

Haas, CS

Amann, K

Wegner, M

机构：

[1] Univ Erlangen Nurnberg, Inst Biochem, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Med Klin 4, D-91054 Erlangen, Germany

[3] Univ Erlangen Nurnberg, Pathol Anat Inst, D-91054 Erlangen, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 118卷 / 1-2期

关键词：

GCM; kidney; thymus; proximal tubule; S3; segment;

D O I：

10.1016/S0925-4773(02)00239-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mouse Glial Cells Missing a (mGCMa) belongs to a small family of transcription factors named after the prototypical GCM from Drosophila. mGCMa was expected to regulate gliogenesis, but instead found to be primarily expressed during development in trophoblasts of chorion and labyrinth: Its deletion causes abnormal placental labyrinth formation and results in embryonic lethality. He(C)re we identify kidney and thymus as sites of mGCMa expression. In thymus, mGCMa is restricted to few small clusters of cells, in kidney to the S3 segment of proximal tubules. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development. 2002 Elsevier Science Ireland Ltd. All rights reserved.

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页码：175 / 178

页数：4

相关论文

共 13 条

[1] The gcm-motif: A novel DNA-binding motif conserved in Drosophila and mammals [J].

Akiyama, Y ;

Hosoya, T ;

Poole, AM ;

Hotta, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) :14912-14916

[2] The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta [J].

Anson-Cartwright, L ;

Dawson, K ;

Holmyard, D ;

Fisher, SJ ;

Lazzarini, RA ;

Cross, JC .

NATURE GENETICS, 2000, 25 (03) :311-314

[3] REGULATION OF COLLECTING DUCT WATER CHANNEL EXPRESSION BY VASOPRESSIN IN BRATTLEBORO RAT [J].

DIGIOVANNI, SR ;

NIELSEN, S ;

CHRISTENSEN, EI ;

KNEPPER, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (19) :8984-8988

[4] Localization and regulation of the rat renal Na+-K+-2Cl(-) cotransporter, BSC-1 [J].

Ecelbarger, CA ;

Terris, J ;

Hoyer, JR ;

Nielsen, S ;

Wade, JB ;

Knepper, MA .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1996, 271 (03) :F619-F628

[5] Genetic ablation of parathyroid glands reveals another source of parathyroid hormone [J].

Günther, T ;

Chen, ZF ;

Kim, JS ;

Priemel, M ;

Rueger, JM ;

Amling, M ;

Moseley, JM ;

Martin, TJ ;

Anderson, DJ ;

Karsenty, G .

NATURE, 2000, 406 (6792) :199-203

[6]

HUGHES EN, 1981, J BIOL CHEM, V256, P664

[7] Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing [J].

Kim, JS ;

Jones, BW ;

Zock, C ;

Chen, ZF ;

Wang, H ;

Goodman, CS ;

Anderson, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12364-12369

[8] Localization of aquaporin-7 in rat and mouse kidney using RT-PCR, immunoblotting, and immunocytochemistry [J].

Nejsum, LN ;

Elkjær, ML ;

Hager, H ;

Frokiær, J ;

Kwon, TH ;

Nielsen, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 277 (01) :164-170

[9] Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa [J].

Schreiber, J ;

Riethmacher-Sonnenberg, E ;

Riethmacher, D ;

Tuerk, EE ;

Enderich, J ;

Bosl, MR ;

Wegner, M .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (07) :2466-2474

[10] The regulator of early gliogenesis glial cells missing is a transcription factor with a novel type of DNA-binding domain [J].

Schreiber, J ;

Sock, E ;

Wegner, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (09) :4739-4744