Synthesis and Antimicrobial Evaluation of 2-Aminobenzophenone Linked 1,4-Dihydropyridine Derivatives

被引：8

作者：

Li, Pengying ^{[1
]}

Sahore, Ketki ^{[2
]}

Liu, Jianjun ^{[1
]}

Singh, Rajesh K. ^{[2
]}

机构：

[1] Northwest A&F Univ, Coll Forestry, Yangling 712100, Peoples R China

[2] Shivalik Coll Pharm Local Govt Dept Punjab, Dept Pharmaceut Chem, Rupnagar 140126, Punjab, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2014年 / 26卷 / 16期

关键词：

1,4-Dihydropyridine; 2-Aminobenzophenone; Pharmacophore; Antimicrobial activity; TACRINE-DIHYDROPYRIDINE HYBRIDS; BENZOPHENONE; INHIBITORS; DESIGN; AGENTS;

D O I：

10.14233/ajchem.2014.17403

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel aminobenzophenone linked 1,4-dihydropyridines (1,4-DHPs) hybrids were synthesized by incorporating aminobenzophenone moiety on 1,4-dihydropyridines scaffold (5a-f) and characterized by IR, 1 H NMR and CHN elemental analysis. The synthesized compounds were tested for their in vitro antibacterial activity against the Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. Among all the synthesized compounds, compounds 5b, 5c and 5e have shown the maximum activity in their group whereas compounds 5a, 5d, 5f have shown the minimum activity.

引用

页码：5291 / 5294

页数：4

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