Substances of abuse and the blood brain barrier: Interactions with physical exercise

被引：17
作者：
Malkiewicz, Marta A. [1 ,2 ]
Malecki, Andrzej [3 ]
Toborek, Michal [3 ,4 ]
Szarmach, Arkadiusz [5 ]
Winklewski, Pawel J. [5 ,6 ]
机构：
[1] Med Univ Gdansk, Dept Human Physiol, Appl Cognit Neurosci Lab, Tuwima Str 15, PL-80210 Gdansk, Poland
[2] Med Univ Gdansk, Dept Psychiat, Gdansk, Poland
[3] Jerzy Kukuczka Acad Phys Educ, Inst Physiotherapy & Hlth Sci, Katowice, Poland
[4] Univ Miami, Dept Biochem & Mol Biol, Miami, FL 33101 USA
[5] Med Univ Gdansk, Dept Radiol 2, Gdansk, Poland
[6] Med Univ Gdansk, Dept Human Physiol, Gdansk, Poland
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2020年 / 119卷
关键词：
Substances of abuse; Blood brain barrier; Physical exercise; CENTRAL-NERVOUS-SYSTEM; NATIONAL EPIDEMIOLOGIC SURVEY; BARBITURIC-ACID DERIVATIVES; CUE-INDUCED REINSTATEMENT; INDUCED OXIDATIVE STRESS; IN-VITRO MODEL; NITRIC-OXIDE; APOLIPOPROTEIN-E; USE DISORDERS; CIGARETTE CRAVINGS;
D O I：
10.1016/j.neubiorev.2020.09.026
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Substance use disorders pose a common medical, social and financial problem. Among the pathomechanisms of substance use disorders, the disruption and increased permeability of the blood-brain barrier has been recently revealed. Physical exercise appears to be a relatively inexpensive and feasible way to implement behavioral therapy counteracting the blood-brain barrier impairment. Concomitantly, there are also studies supporting a potential protective role of selected substances of abuse in maintaining the blood-brain barrier integrity. In this review, we aim to provide a summary on the modulatory influence of physical exercise, a non-pharmacological intervention, on the blood-brain barrier alterations caused by substances of abuse. Further studies are needed to understand the precise mechanisms that underlie various effects of physical exercise in substance use disorders.
引用
收藏
页码：204 / 216
页数：13
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