Substances of abuse and the blood brain barrier: Interactions with physical exercise

被引：17

作者：

Malkiewicz, Marta A. ^{[1
,2
]}

Malecki, Andrzej ^{[3
]}

Toborek, Michal ^{[3
,4
]}

Szarmach, Arkadiusz ^{[5
]}

Winklewski, Pawel J. ^{[5
,6
]}

机构：

[1] Med Univ Gdansk, Dept Human Physiol, Appl Cognit Neurosci Lab, Tuwima Str 15, PL-80210 Gdansk, Poland

[2] Med Univ Gdansk, Dept Psychiat, Gdansk, Poland

[3] Jerzy Kukuczka Acad Phys Educ, Inst Physiotherapy & Hlth Sci, Katowice, Poland

[4] Univ Miami, Dept Biochem & Mol Biol, Miami, FL 33101 USA

[5] Med Univ Gdansk, Dept Radiol 2, Gdansk, Poland

[6] Med Univ Gdansk, Dept Human Physiol, Gdansk, Poland

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2020年 / 119卷

关键词：

Substances of abuse; Blood brain barrier; Physical exercise; CENTRAL-NERVOUS-SYSTEM; NATIONAL EPIDEMIOLOGIC SURVEY; BARBITURIC-ACID DERIVATIVES; CUE-INDUCED REINSTATEMENT; INDUCED OXIDATIVE STRESS; IN-VITRO MODEL; NITRIC-OXIDE; APOLIPOPROTEIN-E; USE DISORDERS; CIGARETTE CRAVINGS;

D O I：

10.1016/j.neubiorev.2020.09.026

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Substance use disorders pose a common medical, social and financial problem. Among the pathomechanisms of substance use disorders, the disruption and increased permeability of the blood-brain barrier has been recently revealed. Physical exercise appears to be a relatively inexpensive and feasible way to implement behavioral therapy counteracting the blood-brain barrier impairment. Concomitantly, there are also studies supporting a potential protective role of selected substances of abuse in maintaining the blood-brain barrier integrity. In this review, we aim to provide a summary on the modulatory influence of physical exercise, a non-pharmacological intervention, on the blood-brain barrier alterations caused by substances of abuse. Further studies are needed to understand the precise mechanisms that underlie various effects of physical exercise in substance use disorders.

引用

页码：204 / 216

页数：13

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