The role of Ca2+ signalling in the physiology and pathophysiology of exocrine pancreas

被引：2

作者：

Chvanov, Michael ^{[1
]}

Voronina, Svetlana ^{[1
]}

Criddle, David N. ^{[1
]}

Tepikin, Alexei, V ^{[1
]}

机构：

[1] Univ Liverpool, Inst Syst Mol & Integrat Biol, Dept Mol Physiol & Cell Signalling, Crown St, Liverpool L69 3BX, Merseyside, England

来源：

CURRENT OPINION IN PHYSIOLOGY | 2020年 / 17卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

BILE-ACIDS INDUCE; DUCTAL BICARBONATE SECRETION; PERMEABILITY TRANSITION PORE; ACINAR-CELLS; RYANODINE RECEPTOR; STELLATE CELLS; ENDOPLASMIC-RETICULUM; ENDOCYTIC VACUOLES; CALCIUM-ENTRY; ATP DEPLETION;

D O I：

10.1016/j.cophys.2020.07.013

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The purpose of this paper is to describe recent advances in the studies of Ca2+ signalling and its physiological/pathophysiological roles in the cells of exocrine pancreas. The review is primarily focused on pancreatic acinar cells - this reflects the importance of this cell type for unravelling of Ca2+ signalling mechanisms and downstream functions. Valuable information on the functional relevance of Ca2+ signalling was also recently obtained in studies of pancreatic ductal cells and pancreatic stellate cells; progress in the studies of these cell types is also briefly summarised in this paper.

引用

页码：96 / 105

页数：10

共 113 条

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