The role of Ca2+ signalling in the physiology and pathophysiology of exocrine pancreas

被引：2
作者：
Chvanov, Michael [1 ]
Voronina, Svetlana [1 ]
Criddle, David N. [1 ]
Tepikin, Alexei, V [1 ]
机构：
[1] Univ Liverpool, Inst Syst Mol & Integrat Biol, Dept Mol Physiol & Cell Signalling, Crown St, Liverpool L69 3BX, Merseyside, England
来源：
CURRENT OPINION IN PHYSIOLOGY | 2020年 / 17卷
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
BILE-ACIDS INDUCE; DUCTAL BICARBONATE SECRETION; PERMEABILITY TRANSITION PORE; ACINAR-CELLS; RYANODINE RECEPTOR; STELLATE CELLS; ENDOPLASMIC-RETICULUM; ENDOCYTIC VACUOLES; CALCIUM-ENTRY; ATP DEPLETION;
D O I：
10.1016/j.cophys.2020.07.013
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The purpose of this paper is to describe recent advances in the studies of Ca2+ signalling and its physiological/pathophysiological roles in the cells of exocrine pancreas. The review is primarily focused on pancreatic acinar cells - this reflects the importance of this cell type for unravelling of Ca2+ signalling mechanisms and downstream functions. Valuable information on the functional relevance of Ca2+ signalling was also recently obtained in studies of pancreatic ductal cells and pancreatic stellate cells; progress in the studies of these cell types is also briefly summarised in this paper.
引用
收藏
页码：96 / 105
页数：10
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