Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?

被引：53

作者：

Young, Michael J. ^{[1
]}

O'Hare, Meabh ^{[1
]}

Matiello, Marcelo ^{[1
]}

Schmahmann, Jeremy D. ^{[1
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2020年 / 89卷

关键词：

COVID-19; Prion disease; Neurodegeneration; Psychoneuroimmunology; INFLAMMATION;

D O I：

10.1016/j.bbi.2020.07.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe a man whose first manifestations of Creutzfeldt-Jakob disease occurred in tandem with symptomatic onset of coronavirus disease 2019 (COVID-19). Drawing from recent data on prion disease pathogenesis and immune responses to SARS-CoV-2, we hypothesize that the cascade of systemic inflammatory mediators in response to the virus accelerated the pathogenesis of our patient's prion disease. This hypothesis introduces the potential relationship between immune responses to the novel coronavirus and the hastening of preclinical or manifest neurodegenerative disorders. The global prevalence of both COVID-19 and neurodegenerative disorders adds urgency to the study of this potential relationship.

引用

页码：601 / 603

页数：3

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