ATM heterozygosity and cancer risk

被引：39

作者：

Concannon, P ^{[1
]}

机构：

[1] Virginia Mason Res Ctr, Mol Genet Program, Seattle, WA 98101 USA

来源：

NATURE GENETICS | 2002年 / 32卷 / 01期

关键词：

D O I：

10.1038/ng0902-89

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Biallelic mutations in ATM cause the recessive disorder ataxia-telangiectasia that is characterized by an increased susceptibility to cancer, but the link between single-copy ATM mutations and cancer has been more difficult to establish. New studies implicate missense mutations in ATM and suggest a model based on dominant interference in heterozygotes.

引用

页码：89 / 90

页数：2

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