Immune response modulation by vitamin D: role in systemic lupus erythematosus

被引：46
作者：
Iruretagoyena, Mirentxu [1 ]
Hirigoyen, Daniela [1 ]
Naves, Rodrigo [2 ]
Isabel Burgos, Paula [1 ]
机构：
[1] Pontificia Univ Catolica Chile, Fac Med, Dept Inmunol Clin & Reumatol, Santiago 8330033, Chile
[2] Univ Chile, Fac Med, Inst Ciencias Biomed, Program Immunol, Santiago 7, Chile
来源：
FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷
关键词：
vitamin D; systemic lupus erythematosus; DIFFERENT MONTHLY REGIMENS; VDR GENE POLYMORPHISMS; DISEASE-ACTIVITY; D DEFICIENCY; 1,25-DIHYDROXYVITAMIN D-3; CARDIOVASCULAR-DISEASE; DIHYDROXYVITAMIN D-3; AUTOIMMUNE-DISEASES; 25-HYDROXYVITAMIN D; D SUPPLEMENTATION;
D O I：
10.3389/fimmu.2015.00513
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vitamin D plays key roles as a natural immune modulator and has been implicated in the pathophysiology of autoimmune diseases, including systemic lupus erythematosus (SLE). This review presents a summary and analysis of the recent literature regarding immunoregulatory effects of vitamin D as well as its importance in SLE development, clinical severity, and possible effects of supplementation in disease treatment.
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页数：7
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