Disposition of linezolid or daptomycin in Enterococcal bloodstream infections according to vancomycin resistant Enterococcus colonization

被引：4

作者：

Short, Elizabeth ^{[1
]}

Esterly, John ^{[1
,2
]}

Postelnick, Michael ^{[1
]}

Ong, Jeannie ^{[3
]}

McLaughlin, Milena ^{[1
,4
]}

机构：

[1] NW Mem Hosp, Dept Pharm, Chicago, IL 60611 USA

[2] Chicago State Univ, Dept Pharm Practice, Coll Pharm, Chicago, IL 60628 USA

[3] Midwestern Univ, Chicago Coll Pharm, Downers Grove, IL 60515 USA

[4] Midwestern Univ, Chicago Coll Pharm, Dept Pharm Practice, Downers Grove, IL 60515 USA

来源：

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL | 2014年 / 3卷

关键词：

VRE; Enterococcus; Vancomycin-resistant Enterococcus; Linezolid; Daptomycin; De-escalation; FAECIUM; VRE; BACTEREMIA;

D O I：

10.1186/2047-2994-3-37

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Vancomycin resistant Enterococcus (VRE) colonized patients are likely to receive VRE targeted Gram-positive antibiotics and may not be de-escalated appropriately once final cultures are available. A retrospective cohort study was conducted in VRE-colonized and non-VRE colonized patients with Enterococcal bloodstream infections. Of 101 patients (n = 50 VRE-colonized; n = 51 non-colonized), empiric therapy with linezolid or daptomycin was started more often in VRE-colonized than non-colonized patients (n = 8, 15.5% vs n = 27, 54%, p < 0.01). There was no difference in de-escalation once VRE infection was ruled out (non-colonized, n = 2, 66.7% vs VRE-colonized, n = 2, 50%, p = 0.09). This study encourages continued stewardship vigilance to decrease inappropriate antibiotic use.

引用

页数：3

共 9 条

[1] National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004 [J].