Update of the statements on biology and clinical impact of occult hepatitis B virus infection

被引：431

作者：

Raimondo, Giovanni ^{[1
,2
]}

Locarnini, Stephen ^{[3
]}

Pollicino, Teresa ^{[1
,4
]}

Levrero, Massimo ^{[5
]}

Zoulim, Fabien ^{[5
]}

Lok, Anna S. ^{[6
]}

Allain, Jean-Pierre ^{[7
]}

Berg, Thomas ^{[8
]}

Bertoletti, Antonio ^{[9
]}

Brunetto, Maurizia Rossana ^{[10
,11
]}

Bruno, Raffaele ^{[12
]}

Chen, Ding-Shinn ^{[13
]}

Coppola, Nicola ^{[14
]}

Cornberg, Markus ^{[15
]}

Craxi, Antonio ^{[16
]}

Dandri, Maura ^{[17
]}

Di Marco, Vito ^{[18
]}

Ferrari, Carlo ^{[19
]}

Gaeta, Giovanni Battista ^{[20
]}

Glebe, Dieter ^{[21
]}

Guidotti, Luca G. ^{[22
]}

Kramvis, Anna ^{[23
]}

Lampertico, Pietro ^{[24
]}

Li, Chengyao ^{[25
]}

Liang, Jake ^{[26
]}

Marzano, Alfredo ^{[27
]}

Michalak, Thomas, I ^{[28
]}

Pawlotsky, Jean-Michel ^{[29
,30
]}

Prati, Daniele ^{[31
]}

Puoti, Massimo ^{[32
]}

Samuel, Didier ^{[33
]}

Soriano, Vincent ^{[34
]}

Squadrito, Giovanni ^{[35
]}

Sureau, Camille ^{[36
]}

Trepo, Christian ^{[37
]}

Yuen, Man-Fung ^{[38
]}

机构：

[1] Univ Messina, Div Clin & Mol Hepatol, Messina, Italy

[2] Univ Messina, Dept Clin & Expt Med, Messina, Italy

[3] Doherty Inst, Victorian Infect Dis Reference Lab, Melbourne, Vic, Australia

[4] Univ Messina, Dept Human Pathol, Messina, Italy

[5] Lyon Univ, Hosp Civils Lyon, Canc Res Ctr Lyon, INSERM U1052, Lyon, France

[6] Univ Michigan, Div Gastroenterol & Hepatol, Ann Arbor, MI 48109 USA

[7] Univ Cambridge, Dept Haematol, Cambridge, England

[8] Univ Hosp, Dept Hepatol, Leipzig, Germany

[9] Singapore Inst Clin Sci, Singapore, Singapore

[10] Pisa Univ, Dept Clin & Expt Med, Internal Med, Pisa, Italy

[11] Univ Hosp Pisa, Pisa, Italy

[12] Univ Pavia, Div Infect Dis, Pavia, Italy

[13] Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei, Taiwan

[14] Univ Campania, Infect Dis Unit, Caserta, Italy

[15] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany

[16] Univ Hosp Palermo, Div Gastroenterol & Hepatol, Palermo, Italy

[17] Univ Med Ctr Hamburg Eppendorf, Dept Internal Med, Hamburg, Germany

[18] Univ Hosp Palermo, Palermo, Italy

[19] Univ Parma, Dept Med & Surg, Parma, Italy

[20] Univ Campania, Div Infect Dis, Naples, Italy

[21] Justus Liebig Univ Giessen, Natl Reference Ctr Hepatitis B&D Viruses, Biomed Res Ctr Seltersberg, Inst Med Virol, Giessen, Germany

[22] IRCCS San Raffaele Sci Inst, Milan, Italy

[23] Univ Witwatersrand, Dept Internal Med, Hepatitis Virus Divers Res Unit, Johannesburg, South Africa

[24] Policlin Milan, Div Gastroenterol & Hepatol, Fdn IRCCS Ca Granda Osped Maggiore, Milan, Italy

[25] Southern Med Univ, Sch Lab Med & Biotechnol, Dept Transfus Med, Guangzhou, Guangdong, Peoples R China

[26] NIDDK, NIH, Bethesda, MD 20892 USA

[27] Univ Hosp Torino, Div Gastroenterol, Turin, Italy

[28] Mem Univ, Fac Med, St John, NF, Canada

[29] Univ Paris Est, Henri Mondor Hosp, Dept Virol, Creteil, France

[30] Univ Paris Est, Henri Mondor Hosp, INSERM U955, Creteil, France

[31] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Transfus Med & Hematol, Milan, Italy

[32] Osped Niguarda Ca Granda, Div Infect Dis, Milan, Italy

[33] Univ Hop Paul Brousse, Ctr Hepatobiliaire, Villejuif, France

[34] La Paz Univ Madrid, UNIR Hlth Sci Sch & Infect Dis & Trop Med, Madrid, Spain

[35] Univ Messina, Dept Clin & Expt Med, Div Clin & Mol Hepatol, Messina, Italy

[36] INSERM, Transfus Inst Natl Transfus Sanguine, U134, Paris, France

[37] Hosp Civils Lyon, Internal Med Dept, Lyon, France

[38] Univ Hong Kong, Kong Queen Hosp, Dept Med, Hong Kong, Peoples R China

来源：

JOURNAL OF HEPATOLOGY | 2019年 / 71卷 / 02期

关键词：

Occult HBV infection; OBI; HBV cccDNA; HBV S variants; HBV transmission; HBV reactivation; Hepatocellular carcinoma; HBSAG-POSITIVE MOTHERS; STEM-CELL TRANSPLANTATION; CHRONIC LIVER-DISEASE; SURFACE-ANTIGEN; HBV INFECTION; BLOOD-DONORS; HEPATOCELLULAR-CARCINOMA; HIGH PREVALENCE; CHILDREN BORN; S-GENE;

D O I：

10.1016/j.jhep.2019.03.034

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In October 2018 a large number of international experts with complementary expertise came together in Taormina to participate in a workshop on occult hepatitis B virus infection (OBI). The objectives of the workshop were to review the existing knowledge on OBI, to identify issues that require further investigation, to highlight both existing controversies and newly emerging perspectives, and ultimately to update the statements previously agreed in 2008. This paper represents the output from the workshop. (C) 2019 European Association for the Study of the Liver. Published by Elsevier B.V.

引用

页码：397 / 408

页数：12

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