Functional ingredients and cardiovascular protective effect of pumpkin seed oils

被引：14
作者：
Al-Okbi, S. Y. [1 ]
Mohamed, D. A. [1 ]
Kandil, E. [2 ]
Ahmed, E. K. [2 ]
Mohammed, S. E. [1 ]
机构：
[1] Natl Res Ctr, Dept Food Sci & Nutr, Cairo, Egypt
[2] Ain Shams Univ, Fac Sci, Dept Biochem, Cairo, Egypt
来源：
GRASAS Y ACEITES | 2014年 / 65卷 / 01期
关键词：
Adiponectin; European and Egyptian PSO; Hypercholesterolemia; Lipid profile; Oxidative stress; Rats; PLASMA-LIPID PROFILE; FATTY-ACIDS; VITAMIN-E; ENDOTHELIAL DYSFUNCTION; TOCOPHEROL CONTENT; OXIDATIVE STRESS; ALPHA-TOCOPHEROL; PLANT STEROLS; HYPOADIPONECTINEMIA; ADIPONECTIN;
D O I：
10.3989/gya.062813
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The objective of the present study was to evaluate the cardiovascular protective effect of Egyptian and European pumpkin seed oil (PSO) in hypercholesterolemic rats. Tocopherols, fatty acids (FAs) and unsaponifiable matter (UNSAP) were assessed in both oils. The results showed that a-tocopherol was 108 and 273, y-tocopherol was 3.95 and 0 and 8-tocopherol was 0 and 1.58 mg-100 g-1 oil of the Egyptian and European, respectively. GLC analysis of FAs revealed the presence of linoleic acid as the major fatty acid in both oils. Feeding a hypercholesterolemic diet produced a significant increase in plasma total cholesterol (T-Ch), triglycerides (TGs), low density lipoprotein cholesterol, T-Ch/HDL-Ch, TGs/HDL-Ch and malondialdehyde and a significant reduction in high density lipoprotein cholesterol (HDL-Ch), vitamin E, and adiponectin. Rats fed on hypercholesterolemic diet with either oil showed a significant improvement in all biochemical parameters.
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页数：10
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