Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation

被引：113

作者：

Murakami, A

Takahashi, M

Jiwajinda, S

Koshimizu, K

Ohigashi, H ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Kyoto 6068502, Japan

[2] Kinki Univ, Fac Biol Oriented Sci & Technol, Dept Biotechnol Sci, Wakayama 6496493, Japan

[3] Kasetsart Univ, Cent Lab & Greenhouse Complex, Environm Sci Unit, Bangkok, Thailand

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1999年 / 63卷 / 10期

关键词：

zerumbone; Epstein-Barr virus; anti-tumor promoter; chemo prevention; Zingiber zerumbet;

D O I：

10.1271/bbb.63.1811

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zerumbone was isolated from the rhizomes of Zingiber zerumbet Smith as a potent inhibitor of tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation, The IC50 value of zerumbone (0.14 mu M) is noticeably lower than those of the anti-tumor promoters we have hitherto obtained. Interestingly, alpha-humulene lacking the carbonyl group at the 8-position in zerumbone was inactive (IC50 > 100 mu M), while 8-hydroxy-alpha-humulune was markedly active (IC50 = 0.95 mu M).

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页码：1811 / 1812

页数：2

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