Rapamycin promotes Schwann cell migration and nerve growth factor secretion

被引:14
作者
Liu, Fang [1 ]
Zhang, Haiwei [1 ]
Zhang, Kaiming [1 ]
Wang, Xinyu [2 ,3 ]
Li, Shipu [2 ,3 ]
Yin, Yixia [2 ,3 ]
机构
[1] Second Hosp Yueyang, Dept Orthoped, Yueyang, Hunan, Peoples R China
[2] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Hunan, Peoples R China
[3] Wuhan Univ Technol, Biomed Mat & Engn Ctr, Wuhan 430070, Hunan Province, Peoples R China
基金
中国国家自然科学基金;
关键词
nerve regeneration; peripheral nerve injury; rapamycin; FK506; Schwann cell; cell migration; nerve growth factor; growth-associated protein 43; NSFC grant; neural regeneration; MYCOPHENOLATE-MOFETIL; CYCLOSPORINE-A; IN-VITRO; HEART-TRANSPLANTATION; NEURITE OUTGROWTH; PC12; CELLS; FK506; REGENERATION; TACROLIMUS; PROTEIN;
D O I
10.4103/1673-5374.130101
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Rapamycin, similar to FK506, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the effects of different concentrations of rapamycin and FK506 on Sc hwann cells and investigated effects and mechanisms of rapamycin on improving peripheral nerve regeneration. Results demonstrated that the lowest rapamycin concentration (1.53 nmol/L) more significantly promoted Schwann cell migration than the highest FK506 concentration (100 mu mol/L). Rapamycin promoted the secretion of nerve growth factors and upregulated growth-associated protein 43 expression in Schwann cells, but did not significantly affect Schwann cell proliferation. Therefore, rapamycin has potential application in peripheral nerve regeneration therapy.
引用
收藏
页码:602 / 609
页数:8
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