Endocytosis via caveolae

被引：578

作者：

Pelkmans, L ^{[1
]}

Helenius, A ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, HPM, ETH Hoenggerberg, CH-8093 Zurich, Switzerland

来源：

TRAFFIC | 2002年 / 3卷 / 05期

关键词：

caveolae; caveosomes; endocytosis; GPI-anchored; proteins; glycosphingolipids; lipid rafts; Simian Virus 40;

D O I：

10.1034/j.1600-0854.2002.30501.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Caveolae are flask-shaped invaginations present in the plasma membrane of many cell types. They have long been implicated in endocytosis, transcytosis, and cell signaling. Recent work has confirmed that caveolae are directly involved in the internalization of membrane components (glycosphingolipids and glycosylphosphatidylinositol-anchored proteins), extracellular ligands (folic acid, albumin, autocrine motility factor), bacterial toxins (cholera toxin, tetanus toxin), and several nonenveloped viruses (Simian virus 40, Polyoma virus). Unlike clathrin-mediated endocytosis, internalization through caveolae is a triggered event that involves complex signaling. The mechanism of internalization and the subsequent intracellular pathways that the internalized substances take are starting to emerge.

引用

页码：311 / 320

页数：10

共 106 条

[1] Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae [J].

Anderson, HA ;

Chen, YZ ;

Norkin, LC .

MOLECULAR BIOLOGY OF THE CELL, 1996, 7 (11) :1825-1834

[2] MHC class I molecules are enriched in caveolae but do not enter with simian virus 40 [J].

Anderson, HA ;

Chen, YZ ;

Norkin, LC .

JOURNAL OF GENERAL VIROLOGY, 1998, 79 :1469-1477

[3] POTOCYTOSIS - SEQUESTRATION AND TRANSPORT OF SMALL MOLECULES BY CAVEOLAE [J].

ANDERSON, RGW ;

KAMEN, BA ;

ROTHBERG, KG ;

LACEY, SW .

SCIENCE, 1992, 255 (5043) :410-411

[4] The caveolae membrane system [J].

Anderson, RGW .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :199-225

[5] Tyrosine phosphorylation of caveolin-1 in the endothelium [J].

Aoki, T ;

Nomura, R ;

Fujimoto, T .

EXPERIMENTAL CELL RESEARCH, 1999, 253 (02) :629-636

[6] CLASS-I MAJOR HISTOCOMPATIBILITY PROTEINS AS CELL-SURFACE RECEPTORS FOR SIMIAN VIRUS-40 [J].

ATWOOD, WJ ;

NORKIN, LC .

JOURNAL OF VIROLOGY, 1989, 63 (10) :4474-4477

[7] Localization of autocrine motility factor receptor to caveolae and clathrin-independent internalization of its ligand to smooth endoplasmic reticulum [J].

Benlimame, N ;

Le, PU ;

Nabi, IR .

MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (07) :1773-1786

[8] CLASS-I MAJOR HISTOCOMPATIBILITY PROTEINS ARE AN ESSENTIAL COMPONENT OF THE SIMIAN VIRUS-40 RECEPTOR [J].

BREAU, WC ;

ATWOOD, WJ ;

NORKIN, LC .

JOURNAL OF VIROLOGY, 1992, 66 (04) :2037-2045

[9] Biological basket weaving: Formation and function of clathrin-coated vesicles [J].

Brodsky, FM ;

Chen, CY ;

Knuehl, C ;

Towler, MC ;

Wakeham, DE .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2001, 17 :517-568

[10] Functions of lipid rafts in biological membranes [J].

Brown, DA ;

London, E .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1998, 14 :111-136

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