Degradation mechanism of magnesium alloy stent under simulated human micro-stress environment

被引:32
作者
Liu, Dexue
Hu, Shiwen
Yin, Xunyan
Liu, Jianjun
Jia, Zhi
Li, Qinglin
机构
[1] State Key Lab Adv Proc & Recycling Nonferrous Met, Lanzhou 730050, Gansu, Peoples R China
[2] Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Gansu, Peoples R China
来源
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2018年 / 84卷
基金
中国国家自然科学基金;
关键词
Magnesium alloy stent; Fluid-structure interaction; Wall shear stress; Impedance pump; Degradation; IN-VITRO CORROSION; SURFACE MODIFICATION; BODY-FLUID; BIOCOMPATIBILITY; MG; BEHAVIOR; IMPLANT;
D O I
10.1016/j.msec.2017.12.001
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
In this study, a vascular stent made of WE43 magnesium alloy was used as a research object and placed in a special physical simulation device constructed independently. This device provided a platform for the study of the degradation of the stent in a dynamic environment. The simulated body fluid of Hank's buffered salt solution flowing inside it would not only make the stent corroded but also apply cyclic shear stress to it, which get closer to the micro-stress environment in human blood vessels. In addition, by means of computer numerical simulation software, ANSYS Fluent 15.0, the fluid-structure interaction (FSI) model was established to simulate the wall shear stress (WSS) exerted by the flowing blood on stent in the blood vessel. Combined with the results of numerical simulation and physical simulation experiments, the degradation mechanism of magnesium alloy sent in an environment similar to the human blood vessels was studied.
引用
收藏
页码:263 / 270
页数:8
相关论文
共 27 条
[1]   Corrosion behaviour of AZ31 magnesium alloy with different grain sizes in simulated biological fluids [J].
Alvarez-Lopez, M. ;
Dolores Pereda, Maria ;
del Valle, J. A. ;
Fernandez-Lorenzo, M. ;
Garcia-Alonso, M. C. ;
Ruano, O. A. ;
Escudero, M. L. .
ACTA BIOMATERIALIA, 2010, 6 (05) :1763-1771
[2]   Corrosion fatigue of biomedical metallic alloys: Mechanisms and mitigation [J].
Antunes, Renato Altobelli ;
Lopes de Oliveira, Mara Cristina .
ACTA BIOMATERIALIA, 2012, 8 (03) :937-962
[3]  
DI MC, 2004, J INTERV CARDIOL, V17, P391
[4]   Long-term in vivo degradation behaviour and biocompatibility of the magnesium alloy ZEK100 for use as a biodegradable bone implant [J].
Dziuba, Dina ;
Meyer-Lindenberg, Andrea ;
Seitz, Jan Marten ;
Waizy, Hazibullah ;
Angrisani, Nina ;
Reifenrath, Janin .
ACTA BIOMATERIALIA, 2013, 9 (10) :8548-8560
[5]   Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents:: a prospective, non-randomised multicentre trial [J].
Erbel, Raimund ;
Di Mario, Carlo ;
Bartunek, Jozef ;
Bonnier, Johann ;
de Bruyne, Bernard ;
Eberli, Franz R. ;
Erne, Paul ;
Haude, Michael ;
Heublein, Bernd ;
Horrigan, Mark ;
Ilsley, Charles ;
Boese, Dirk ;
Koolen, Jacques ;
Luescher, Thomas F. ;
Weissman, Neil ;
Waksman, Ron .
LANCET, 2007, 369 (9576) :1869-1875
[6]   Interference of magnesium corrosion with tetrazolium-based cytotoxicity assays [J].
Fischer, Janine ;
Prosenc, Marc H. ;
Wolff, Martin ;
Hort, Norbert ;
Willumeit, Regine ;
Feyerabend, Frank .
ACTA BIOMATERIALIA, 2010, 6 (05) :1813-1823
[7]   Influence of surface modification on the in vitro corrosion rate of magnesium alloy AZ31 [J].
Gray-Munro, Joy E. ;
Seguin, Christine ;
Strong, Michael .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2009, 91A (01) :221-230
[8]   In vitro and in vivo studies on a Mg-Sr binary alloy system developed as a new kind of biodegradable metal [J].
Gu, X. N. ;
Xie, X. H. ;
Li, N. ;
Zheng, Y. F. ;
Qin, L. .
ACTA BIOMATERIALIA, 2012, 8 (06) :2360-2374
[9]   In vitro corrosion and biocompatibility of binary magnesium alloys [J].
Gu, Xuenan ;
Zheng, Yufeng ;
Cheng, Yan ;
Zhong, Shengping ;
Xi, Tingfei .
BIOMATERIALS, 2009, 30 (04) :484-498
[10]   Developments in metallic biodegradable stents [J].
Hermawan, H. ;
Dube, D. ;
Mantovani, D. .
ACTA BIOMATERIALIA, 2010, 6 (05) :1693-1697