One-Step Hydrothermal Synthesis of Nitrogen-Doped Conjugated Carbonized Polymer Dots with 31% Efficient Red Emission for In Vivo Imaging

被引:468
作者
Liu, JunJun [1 ]
Li, Daowei [2 ]
Zhang, Kai [1 ]
Yang, Mingxi [1 ]
Sun, Hongchen [2 ]
Yang, Bai [1 ]
机构
[1] Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Jilin, Peoples R China
[2] Jilin Univ, Coll & Hosp Stomatol, Dept Oral Pathol, Changchun 130012, Jilin, Peoples R China
基金
美国国家科学基金会; 中国国家自然科学基金;
关键词
carbonized polymer dots; high-efficient red emission; hydrothermal synthesis; in vivo imaging; narrow bandwidth emission; GRAPHENE QUANTUM DOTS; FULL-COLOR EMISSION; PHOTOLUMINESCENCE MECHANISM; O-PHENYLENEDIAMINE; NANODOTS; LUMINESCENCE; PH; THERAPY; COMPLEX; STATE;
D O I
10.1002/smll.201703919
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Carbon dots with long-wavelength emissions, high quantum yield (QY) and good biocompatibility are highly desirable for biomedical applications. Herein, a green, facile hydrothermal synthesis of highly efficient red emissive nitrogen-doped carbonized polymer dots (CPDs) with optimal emission at around 630 nm are reported. The red emissive CPDs possess a variety of superior properties including excellent water dispersibility, good biocompatibility, narrow bandwidth emission, an excitation-independent emission, and high QY (10.83% (in water) and 31.54% (in ethanol)). Further studies prove that such strong red fluorescence is ascribed to the efficient conjugated aromatic systems and hydrogen bonds of CPDs. And the fluorescence properties of CPDs can be regulated by adjusting the dosage of HNO3 before the reaction. Additionally, the as-prepared CPDs are successfully used as a fluorescent probe for bioimaging, both in vitro and in vivo. More importantly, biodistribution results demonstrate that most CPDs and their metabolites are not only excreted in urine but also excreted by hepatobiliary system in a rapid manner. Besides, the CPDs could easily cross the blood brain barrier, which may provide a valuable strategy for the theranostics of some brain diseases through real-time tracking.
引用
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页数:10
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