Effects of inhaled nitric oxide in COVID-19-induced ARDS - Is it worthwhile?

被引：57

作者：

Lotz, Christopher ^{[1
]}

Muellenbach, Ralf M. ^{[2
]}

Meybohm, Patrick ^{[1
]}

Mutlak, Haitham ^{[3
]}

Lepper, Philipp M. ^{[4
]}

Rolfes, Caroline-Barbara ^{[2
]}

Peivandi, Asghar ^{[5
]}

Stumpner, Jan ^{[1
]}

Kredel, Markus ^{[1
]}

Kranke, Peter ^{[1
]}

Torje, Iuliu ^{[2
]}

Reyher, Christian ^{[2
]}

机构：

[1] Univ Wurzburg, Dept Anaesthesiol & Crit Care Med, Wurzburg, Germany

[2] Univ Southampton, Dept Crit Care Emergency Med & Anaesthesiol, ARDS ECMO Ctr, Kassel, Germany

[3] Sana Klinikum Offenbach, Dept Anaesthesiol Intens Care & Emergency, Kassel, Germany

[4] Saarland Univ, Dept Internal Med Pulmonol Allergol & Crit Care 5, Homburg, Germany

[5] Univ Southampton, ARDS ECMO Ctr, Dept Cardiovasc Surg, Kassel, Germany

来源：

ACTA ANAESTHESIOLOGICA SCANDINAVICA | 2021年 / 65卷 / 05期

关键词：

ARDS; COVID-19; nitric oxide; vasoreactivity;

D O I：

10.1111/aas.13757

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Background Changes in pulmonary hemodynamics and ventilation/perfusion were proposed as hallmarks of Coronavirus disease 2019 (COVID-19)-induced acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) may overcome these issues and improve arterial oxygenation. Methods We retrospectively analyzed arterial oxygenation and pulmonary vasoreactivity in seven COVID-19 ARDS patients receiving 20 ppm iNO for 15-30 minutes. Results The inhalation of NO significantly improved oxygenation. All patients with severe ARDS had higher partial pressures of oxygen and reduced pulmonary vascular resistance. Significant changes in pulmonary shunting were not observed. Conclusion Overall, iNO could provide immediate help and delay respiratory deterioration in COVID-19-induced moderate to severe ARDS.

引用

页码：629 / 632

页数：4

共 10 条

[1] Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus [J].

Åkerström, S ;

Mousavi-Jazi, M ;

Klingström, J ;

Leijon, M ;

Lundkvist, Å ;

Mirazimi, A .

JOURNAL OF VIROLOGY, 2005, 79 (03) :1966-1969

[2] COVID-19 pneumonia: different respiratory treatments for different phenotypes? [J].

Gattinoni, Luciano ;

Chiumello, Davide ;

Caironi, Pietro ;

Busana, Mattia ;

Romitti, Federica ;

Brazzi, Luca ;

Camporota, Luigi .

INTENSIVE CARE MEDICINE, 2020, 46 (06) :1099-1102

[3] Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults [J].

Gebistorf, Fabienne ;

Karam, Oliver ;

Wetterslev, Jorn ;

Afshari, Arash .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2016, (06)

[4] Long-term response to calcium-channel blockers in non-idiopathic pulmonary arterial hypertension [J].

Montani, David ;

Savale, Laurent ;

Natali, Delphine ;

Jais, Xavier ;

Herve, Philippe ;

Garcia, Gilles ;

Humbert, Marc ;

Simonneau, Gerald ;

Sitbon, Olivier .

EUROPEAN HEART JOURNAL, 2010, 31 (15) :1898-1907

[5] FIFTY YEARS OF RESEARCH IN ARDS Gas Exchange in Acute Respiratory Distress Syndrome [J].

Radermacher, Peter ;

Maggiore, Salvatore Maurizio ;

Mercat, Alain .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 196 (08) :964-984

[6] Acute Respiratory Distress Syndrome The Berlin Definition [J].

Ranieri, V. Marco ;

Rubenfeld, Gordon D. ;

Thompson, B. Taylor ;

Ferguson, Niall D. ;

Caldwell, Ellen ;

Fan, Eddy ;

Camporota, Luigi ;

Slutsky, Arthur S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (23) :2526-2533

[7] INHALED NITRIC-OXIDE FOR THE ADULT RESPIRATORY-DISTRESS SYNDROME [J].

ROSSAINT, R ;

FALKE, KJ ;

LOPEZ, F ;

SLAMA, K ;

PISON, U ;

ZAPOL, WM .

NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (06) :399-405

[8] Nitric oxide in the lung: therapeutic and cellular mechanisms of action [J].

Weinberger, B ;

Heck, DE ;

Laskin, DL ;

Laskin, JD .

PHARMACOLOGY & THERAPEUTICS, 1999, 84 (03) :401-411

[9]

World Health Organization, 2020, LAB TEST 2019 NOV CO

[10] Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study [J].

Zhou, Fei ;

Yu, Ting ;

Du, Ronghui ;

Fan, Guohui ;

Liu, Ying ;

Liu, Zhibo ;

Xiang, Jie ;

Wang, Yeming ;

Song, Bin ;

Gu, Xiaoying ;

Guan, Lulu ;

Wei, Yuan ;

Li, Hui ;

Wu, Xudong ;

Xu, Jiuyang ;

Tu, Shengjin ;

Zhang, Yi ;

Chen, Hua ;

Cao, Bin .

LANCET, 2020, 395 (10229) :1054-1062

← 1 →