Leishmania infantum: illness, transmission profile and risk factors for asymptomatic infection in an endemic metropolis in Brazil

被引：16

作者：

Dos Santos Marques, Leticia Helena ^{[1
]}

Marques Da Rocha, Iara Caixeta ^{[1
,2
]}

Reis, Ilka Afonso ^{[3
]}

Rodrigues Da Cunha, Gisele Macedo ^{[1
]}

Oliveira, Edward ^{[4
]}

Pfeilsticker, Thais Ribeiro ^{[1
]}

Miranda De Araujo, Valdelaine Etelvina ^{[5
]}

Franco Morais, Maria Helena ^{[2
]}

Rabello, Ana ^{[4
]}

Carneiro, Mariangela ^{[1
,6
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Parasitol, Lab Epidemiol Doencas Infecciosas & Parasitarias, BR-31270901 Belo Horizonte, MG, Brazil

[2] Secretaria Municipal Saude, Prefeitura Belo Horizonte, BR-30710040 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Ciencias Exatas, Dept Estat, Belo Horizonte, MG, Brazil

[4] Fundacao Oswaldo Cruz, Ctr Pesquisas Rene Rachou, Lab Pesquisas Clin, BR-30190002 Belo Horizonte, MG, Brazil

[5] Minist Saude, BR-70058900 Esplanada De Ministerios, DF, Brazil

[6] Univ Fed Minas Gerais, Fac Med, Posgrad Ciencias Saude Infectol & Med Trop, Belo Horizonte, MG, Brazil

来源：

PARASITOLOGY | 2017年 / 144卷 / 04期

关键词：

visceral leishmaniasis; asymptomatic infection; infection; relative risk; Brazil; HUMAN VISCERAL LEISHMANIASIS; URBAN AREA; SPATIAL-ANALYSIS; MINAS-GERAIS; PIAUI STATE; KALA-AZAR; CHAGASI; ASSAY; MANIFESTATIONS; MUNICIPALITY;

D O I：

10.1017/S0031182016002134

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

To evaluate the distribution of asymptomatic infection by Leishmania infantum in ametropolis in Brazil with different relative risks (RRs) for disease and risk factors associated with the infection, an ecological study was conducted using a Bayesian approach to estimate the RR of human visceral leishmaniasis (HVL) based on cases between 2008 and 2011. The areas were categorized and selected according to disease incidence: low (area-1), medium (area-2) and high (area-3). Cross-sectional study enrolling 935 children was used to estimate the prevalence of infection by L. infantum. Volunteers from these three areas were tested for L. infantum infection by ELISA (rK39 and soluble antigens). Infection prevalence rates were estimated and compared with the RR of disease. Multilevel logistic regression model evaluated the relationship between infection and the analysed variables. The RR of HVL was distributed heterogeneously in the municipality. The infection prevalence rates were: 34.9% in area-1; 29.3% in area-2; and 33.6% in area-3, with no significant differences between these areas. The variables 'Presence of backyards in the neighbourhood' and 'Younger children' were associated with L. infantuminfection. We conclude that infection by L. infantum affects a significant proportion of the infant population regardless of the RR of disease.

引用

页码：546 / 556

页数：11

共 38 条

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