Organic Solvent Nanofiltration in Pharmaceutical Industry

被引：164

作者：

Buonomenna, M. G. ^{[1
]}

Bae, J. ^{[2
]}

机构：

[1] Ordine Chim Campania, I-80138 Naples, Italy

[2] Dongduk Womens Univ, Dept Appl Chem, Seoul, South Korea

来源：

SEPARATION AND PURIFICATION REVIEWS | 2015年 / 44卷 / 02期

关键词：

Organic solvent nanofiltration; solvent resistant nanofiltration; active pharmaceutical ingredients (APIs); solvent exchange; product purification; genotoxin impurities (GTIs); membrane enhanced peptide synthesis (MEPS); hybrid processes; POLY(ETHER ETHER KETONE); MEMBRANE FORMATION PARAMETERS; PHASE INVERSION PARAMETERS; CELL-PENETRATING PEPTIDES; RESISTANT NANOFILTRATION; MOLECULAR-WEIGHT; CROSS-LINKING; (OSN)-INTERFACIAL POLYMERIZATION; TRANSPORT-PROPERTIES; COMPOSITE MEMBRANES;

D O I：

10.1080/15422119.2014.918884

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Organic solvent nanofiltration (OSN) is a promising energy and waste efficient unit process to separate mixtures down to a molecular level, which gained attention in the pharmaceutical industry, in particular in the process development of Active Pharmaceutical Ingredients (APIs). This article focuses on all aspects related to OSN (i.e., membrane materials, commercial membranes, transport theories, applications) to understand the role of this technology in pharmaceutical industry. The most important results in the last five years on OSN applications in the process development of APIs are reviewed extensively.

引用

页码：157 / 182

页数：26

共 126 条

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