Synthesis of Aryl Substituted Quinones as β-Secretase Inhibitors: Ligand-Free Direct Arylation of Quinones with Aryl Halides

被引：9

作者：

Wang, Dawei ^{[1
]}

Ge, Bingyang ^{[1
]}

Yang, Shuyan ^{[1
]}

Miao, Hongyan ^{[1
]}

Ding, Yuqiang ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Chem & Mat Engn, Key Lab Food Colloids & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2014年 / 84卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ligand-free; quinones; inhibitors; arylation; Heck reaction; CONJUGATE ADDITION; ARYLBORONIC ACIDS; NAPHTHOQUINONES; BIOSYNTHESIS; ARYLQUINONES; ACTIVATION; DISCOVERY; OXIDATION; INDOLES; WATER;

D O I：

10.1134/S1070363214080295

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The simple ligand-free direct arylation of quinones with aryl halides applying Pd(OAc)(2) as a catalyst in accordance with Heck reaction was studied. This reaction provided a simple and efficient synthetic approach to efficient inhibitors of beta-secretase aryl-substituted quinones.

引用

页码：1615 / 1621

页数：7

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