MR Imaging of Meniere's Disease after Combined Intratympanic and Intravenous Injection of Gadolinium using HYDROPS2

Endolymphatic hydrops (EH) in Meniere's disease is currently evaluated by 3-dimensional (3D)-real inversion recovery (IR) sequence after intratympanic (IT) administration of gadolinium (Gd) or by heavily T-2-weighted (hT2W)-3D-fluid-attenuated IR (FLAIR) sequence after intravenous (IV) injection of Gd. Unilateral IT injection is usually performed. We employed a method in which we simultaneously administered contrast into one ear intravenously (IV side) and into the other ear both intravenously and intratympanically (IT + IV side) to evaluate EH in 10 patients with Meniere's disease. We then compared a HYDROPS2 image obtained by subtracting magnetic resonance cisternography from hT(2)W-3D-FLAIR with an image obtained by 3D-real IR and found that we could evaluate EH in all ears on the HYDROPS2 image but only in the IT + IV side on the 3D-real IR image.