Progress in the search for circulating biomarkers of nonalcoholic fatty liver disease

被引：11
作者：
Amacher, David E. [1 ]
机构：
[1] Sciadvisor Toxicol Consulting, Hadlyme, CT 06439 USA
来源：
BIOMARKERS | 2014年 / 19卷 / 07期
关键词：
Non-alcoholic fatty liver disease; non-alcoholic steatosis; novel circulating biomarkers; steatohepatitis; GROWTH-FACTOR; 21; PROLIDASE ENZYME-ACTIVITY; INDUCED HEPATIC STEATOSIS; C-REACTIVE PROTEIN; SERUM FGF21 LEVELS; NONINVASIVE DIAGNOSIS; SCORING SYSTEM; CELL-DEATH; ALANINE AMINOTRANSFERASE; STEATOHEPATITIS NASH;
D O I：
10.3109/1354750X.2014.958535
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Context: The definitive standard for the diagnosis of nonalcoholic fatty liver disease (NAFLD) is clinico-pathological correlation, but frequently the only laboratory abnormality is an elevation of serum aminotransferases. Objective: This has resulted in the search for more specific laboratory biomarkers. Methods: The literature was searched for novel plasma/serum markers of NAFLD. Results: Studies reviewed here included histologically-confirmed patients presenting some stage of NAFLD and monitored one or more novel serum/plasma biomarkers. Conclusion: The most promising application of some of these novel biomarkers for the detection and quantification of NAFLD and particularly NASH appears to be in the combination of several into diagnostic panels.
引用
收藏
页码：541 / 552
页数：12
相关论文
共 114 条
[1]   Plasma microRNA profiles for bladder cancer detection [J].
Adam, Liana ;
Wszolek, Matthew F. ;
Liu, Chang-Gong ;
Jing, Wang ;
Diao, Lixia ;
Zien, Alexander ;
Zhang, Jitao D. ;
Jackson, David ;
Dinney, Colin P. N. .
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2013, 31 (08) :1701-1708
[2]   Nonalcoholic fatty liver disease [J].
Adams, LA ;
Angulo, P ;
Lindor, KD .
CANADIAN MEDICAL ASSOCIATION JOURNAL, 2005, 172 (07) :899-905
[3]   Drug-Induced Hepatic Steatosis [J].
Amacher, David E. ;
Chalasani, Naga .
SEMINARS IN LIVER DISEASE, 2014, 34 (02) :205-214
[4]   MicroRNAs: Small RNAs With Big Effects [J].
Anglicheau, Dany ;
Muthukumar, Thangamani ;
Suthanthiran, Manikkam .
TRANSPLANTATION, 2010, 90 (02) :105-112
[5]   GI Epidemiology: nonalcoholic fatty liver disease [J].
Angulo, P. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2007, 25 (08) :883-889
[6]   The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD [J].
Angulo, Paul ;
Hui, Jason M. ;
Marchesini, Giulio ;
Bugianesi, Ellisabetta ;
George, Jacob ;
Farrell, Geoffrey C. ;
Enders, Felicity ;
Saksena, Sushma ;
Burt, Alastair D. ;
Bida, John P. ;
Lindor, Keith ;
Sanderson, Schuyler O. ;
Lenzi, Marco ;
Adams, Leon A. ;
Kench, James ;
Therneau, Terry M. ;
Day, Christopher P. .
HEPATOLOGY, 2007, 45 (04) :846-854
[7]   RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity (Publication with Expression of Concern. See vol. 73, pg. 1297, 2020) (Publication with Expression of Concern. See vol. 69, pg. 1402, 2018) (Retracted article. See vol. 73, pg. 1297, 2020) [J].
Antoine, Daniel J. ;
Jenkins, Rosalind E. ;
Dear, James W. ;
Williams, Dominic P. ;
McGill, Mitchell R. ;
Sharpe, Matthew R. ;
Craig, Darren G. ;
Simpson, Kenneth J. ;
Jaeschke, Hartmut ;
Park, B. Kevin .
JOURNAL OF HEPATOLOGY, 2012, 56 (05) :1070-1079
[8]   Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].
Arroyo, Jason D. ;
Chevillet, John R. ;
Kroh, Evan M. ;
Ruf, Ingrid K. ;
Pritchard, Colin C. ;
Gibson, Donald F. ;
Mitchell, Patrick S. ;
Bennett, Christopher F. ;
Pogosova-Agadjanyan, Era L. ;
Stirewalt, Derek L. ;
Tait, Jonathan F. ;
Tewari, Muneesh .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008
[9]   Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease [J].
Barsic, Neven ;
Lerotic, Ivan ;
Smircic-Duvnjak, Lea ;
Tomasic, Vedran ;
Duvnjak, Marko .
WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (30) :3945-3954
[10]   Fructose as a key player in the development of fatty liver disease [J].
Basaranoglu, Metin ;
Basaranoglu, Gokcen ;
Sabuncu, Tevfik ;
Senturk, Hakan .
WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (08) :1166-1172
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