Plasma-treated silk fibroin nanofibers for skin regeneration

被引：77
|
作者：
Jeong, Lim [4 ,5 ]
Yeo, In-Sung [6 ]
Kim, Ha Na [4 ,5 ]
Yoon, Young Il [4 ,5 ]
Jang, Da Hyun [1 ,2 ,3 ]
Jung, Sung Youn [1 ,2 ,3 ]
Min, Byung-Moo [1 ,2 ,3 ]
Park, Won Ho [4 ,5 ]
机构：
[1] Seoul Natl Univ, Sch Dent, Dept Oral Biochem, Seoul 110749, South Korea
[2] Seoul Natl Univ, Sch Dent, Program Craniomaxillofacial Reconstruct Sci, Dent Res Inst, Seoul 110749, South Korea
[3] Seoul Natl Univ, Sch Dent, BK21 CLS, Seoul 110749, South Korea
[4] Chungnam Natl Univ, Dept Adv Organ Mat & Text Syst Engn, Taejon 305764, South Korea
[5] Chungnam Natl Univ, BK21 FTIT, Taejon 305764, South Korea
[6] Seoul Natl Univ, Bundang Hosp, Sect Dent, Gyeonggi Do, South Korea
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2009年 / 44卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
Silk fibroin; Electrospinning; Nanofiber; Plasma treatment; Cell behavior; POLY(D; L-LACTIC ACID); SURFACE MODIFICATION; ATTACHMENT; SCAFFOLDS; ADHESION; CULTURE; BINDING; FILMS;
D O I：
10.1016/j.ijbiomac.2008.12.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Silk fibroin (SF) nanofibers were prepared by electrospinning and treated with plasma in the presence of oxygen or methane gas to modify their surface characteristics. The surface characteristics of the SF nanofibers after plasma treatment were examined using contact angle measurements and XPS analysis. The hydrophilicity of the electrospun SF nanofibers decreased slightly by the CH4 plasma treatment. On the other hand, the hydrophilicity of the SF nanofibers increased greatly by an O-2 plasma treatment. The O-2-treated SF nanofibers showed higher cellular activities for both normal human epidermal keratinocytes (NHEK) and fibroblasts (NHEF) than the untreated ones. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：222 / 228
页数：7
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