To eat or not to eat - the metabolic flavor of ferroptosis

被引：130

作者：

Gao, Minghui ^{[1
,2
]}

Jiang, Xuejun ^{[2
]}

机构：

[1] Harbin Inst Technol, Sch Life Sci & Technol, HIT Ctr Life Sci, Harbin 150080, Heilongjiang, Peoples R China

[2] Mem Sloan Kettering Canc Ctr, Cell Biol Program, 1275 York Ave, New York, NY 10065 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2018年 / 51卷

关键词：

INDUCED CELL-DEATH; GLUTAMINE-METABOLISM; ENERGY-METABOLISM; OXIDATIVE STRESS; IRON HOMEOSTASIS; APOPTOSIS; ACTIVATION; REGULATOR; PATHWAY; DISEASE;

D O I：

10.1016/j.ceb.2017.11.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ferroptosis is a newly defined iron-dependent, non-apoptotic mode of cell death with necrotic morphology. Distinctive from other death mechanisms, ferroptosis requires cellular iron and lipid peroxides, and is dictated by specific cellular metabolic processes. Importantly, ferroptosis has been implicated in a plethora of human diseases. This paper reviews the recent advances and outstanding questions of the field by focusing on the role of cellular metabolism in ferroptosis. The relevance of ferroptosis to disease and therapy is also discussed.

引用

页码：58 / 64

页数：7

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