Copper-mediated trifluoromethylation of aryl-, heteroaryl-, and vinyltrifluoroborates with Langlois' reagent

被引：36

作者：

Dubbaka, Srinivas Reddy ^{[1
]}

Salla, Manohar ^{[1
]}

Bolisetti, Raghu ^{[1
]}

Nizalapur, Shashidhar ^{[1
]}

机构：

[1] Albany Mol Res Singapore Res Ctr Pte Ltd, Dept Med Chem, Singapore 117525, Singapore

来源：

RSC ADVANCES | 2014年 / 4卷 / 13期

关键词：

CROSS-COUPLING REACTIONS; PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; PALLADIUM-CATALYZED TRIFLUOROMETHYLATION; ARYLBORONIC ACIDS; REDUCTIVE ELIMINATION; POTASSIUM ARYL; BOND FORMATION; BORONIC ACIDS; ARENES; FLUORINE;

D O I：

10.1039/c3ra46837b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An effortless and realistic procedure for the copper-mediated trifluoromethylation of aryl-, heteroaryl- and vinyltrifluoroborates with CF3 radicals generated from NaSO2CF3 and tert-butyl hydroperoxide (TBHP) is presented. The developed method produces trifluoromethyl arenes and -alkenes in good to excellent yields and a wide range of electronically and structurally diverse substrates are tolerated.

引用

页码：6496 / 6499

页数：4

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