Synthesis and antioxidant properties of N-substituted aminomethyl derivatives of 2-isobornylphenol

被引：11
|
作者：
Buravlev, E., V [1 ]
Shevchenko, O. G. [2 ]
机构：
[1] Russian Acad Sci, Komi Sci Ctr, Inst Chem, Ural Branch, 48 Ul Pervomayskaya, Syktyvkar 167000, Russia
[2] Russian Acad Sci, Komi Sci Ctr, Inst Biol, Ural Branch, 28 Ul Kommunisticheskaya, Syktyvkar 167982, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2020年 / 69卷 / 10期
关键词：
aminomethylation; Mannich bases; antioxidant activity; membrane-protective activity; erythrocytes; oxidative hemolysis; aminomethyl derivatives of 2-isobornylphenol; HEME DEGRADATION-PRODUCTS; MANNICH-BASES; IN-VITRO; CHEMISTRY; MEMBRANE; ISOBORNYLPHENOL; HEMOGLOBIN; ALKYLATION; XANTHONES; DAMAGE;
D O I：
10.1007/s11172-020-2987-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 2-isobornylphenol derivatives containing aminomethyl groups either at ortho-(monoderivatives) or ortho- and para-positions (bis-derivatives) relative to the hydroxy group of phenol moiety was synthesized. Antioxidant properties of the obtained compounds were comparatively evaluated using in vitro models. It was demonstrated that Mannich bases containing an n-octylaminomethyl group are significantly exceeding both starting 2-isobornylphenol and the standard antioxidant, 2,6-di-tert-butyl-4-methylphenol, by their ability to inhibit H2O2-induced erythrocyte hemolysis.
引用
收藏
页码：1971 / 1978
页数：8
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