Primary Diffuse Large B-Cell Lymphoma of the Uterus: Case Report and Review

被引:6
作者
Mandato, Vincenzo Dario [1 ]
Palermo, Rosalba [1 ]
Falbo, Angela [1 ]
Capodanno, Isabella [2 ]
Capodanno, Francesco [1 ]
Gelli, Maria Carolina [3 ]
Aguzzoli, Lorenzo [1 ]
Abrate, Martino [1 ]
La Sala, Giovanni Battista [1 ,4 ]
机构
[1] IRCCS, Unit Obstet & Gynaecol, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy
[2] IRCCS, Unit Haematol, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy
[3] IRCCS, Unit Pathol, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy
[4] Univ Modena & Reggio Emilia, Reggio Emilia, Italy
关键词
Uterus; cervix; diagnosis; lymphoma; treatment; vaginal bleeding; NON-HODGKINS-LYMPHOMA; PRIMARY MALIGNANT-LYMPHOMA; PRIMARY CERVICAL LYMPHOMA; FEMALE GENITAL-TRACT; UTERINE CERVIX; NEOADJUVANT CHEMOTHERAPY; SUCCESSFUL PREGNANCY; UPPER VAGINA; FEATURES; APPEARANCE;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Primary diffuse large B-cell lymphoma of the cervix is a very rare disease, with non-specific clinical presentation. Its prognosis depends on accurate and timely diagnosis and therapy. Moreover, the management of this tumour has never been standardized. Case Report: Herein we present a rare case of primary diffuse large B-cell lymphoma of the cervix misdiagnosed as cervical myoma. Our systematic review of the English literature identified 143 cases of primary diffuse large B-cell lymphoma of the uterus. Patients' characteristics and oncological, surgical, and safety data were recorded and analyzed. Conclusion: Although rare, primary diffuse large B-cell lymphoma of the cervix should never be ruled-out. Given its non-specific clinical symptoms, a multidisciplinary approach is required to perform a timely diagnosis and administer appropriate therapy. Immunochemotherapy (Rituximab + CHOP or CHOP-like regimen) with/without radiotherapy is the most common and most effective treatment; surgery should be avoided.
引用
收藏
页码:4377 / 4390
页数:14
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