Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study

被引：30

作者：

Endres, Dominique ^{[1
]}

van Elst, Ludger Tebartz ^{[1
]}

Meyer, Simon A. ^{[1
]}

Feige, Bernd ^{[1
]}

Nickel, Kathrin ^{[1
]}

Bubl, Anna ^{[2
]}

Riedel, Andreas ^{[1
]}

Ebert, Dieter ^{[1
]}

Lange, Thomas ^{[3
]}

Glauche, Volkmar ^{[4
]}

Biscaldi, Monica ^{[5
]}

Philipsen, Alexandra ^{[6
]}

Maier, Simon J. ^{[1
]}

Perlov, Evgeniy ^{[1
,7
]}

机构：

[1] Univ Freiburg, Sect Expt Neuropsychiat, Dept Psychiat, Med Ctr Univ Freiburg,Fac Med, Hauptstr 5, D-79104 Freiburg, Germany

[2] Univ Saarland, Dept Psychiat & Psychotherapy, Med Ctr, Kirrberger Str 100, D-66421 Homburg, Saar, Germany

[3] Univ Freiburg, Dept Radiol, Med Ctr Univ Freiburg, Med Phys,Fac Med, Breisacher Str 60a, D-79106 Freiburg, Germany

[4] Univ Freiburg, Med Ctr Univ Freiburg, Fac Med, Dept Neurol, Breisacher Str 64, D-79106 Freiburg, Germany

[5] Univ Freiburg, Dept Child & Adolescent Psychiat & Psychotherapy, Med Ctr Univ Freiburg, Fac Med, Hauptstr 8, D-79104 Freiburg, Germany

[6] Carl von Ossietzky Univ Oldenburg, Sch Med & Hlth Sci Psychiat & Psychotherapy, Univ Hosp, Karl Jaspers Klin, Med Campus,Hermann Ehlers Str 7, D-26160 Bad Zwischenahn, Germany

[7] Clin Psychiat Luzern, Schafmattstr 1, CH-4915 St Urban, Switzerland

来源：

MOLECULAR AUTISM | 2017年 / 8卷

关键词：

Autism spectrum disorder; Asperger syndrome; MR spectroscopy; Glutathione; Anterior cingulate cortex; DLPFC; MAGNETIC-RESONANCE-SPECTROSCOPY; IN-VIVO GLUTATHIONE; ASPERGER-SYNDROME; BIPOLAR DISORDER; OXIDATIVE STRESS; SCHIZOPHRENIA; DEFICIT; STATE; INTELLIGENCE; QUANTITATION;

D O I：

10.1186/s13229-017-0122-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by difficulties in social communication, unusually restricted, repetitive behavior and interests, and specific abnormalities in language and perception. The precise etiology of ASD is still unknown and probably heterogeneous. In a subgroup of patients, toxic environmental exposure might lead to an imbalance between oxidative stress and anti-oxidant systems. Previous serum and postmortem studies measuring levels of glutathione (GSH), the main cellular free radical scavenger in the brain, have supported the hypothesis that this compound might play a role in the pathophysiology of autism. Methods: Using the method of single-voxel proton magnetic resonance spectroscopy (MRS), we analyzed the GSH signal in the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (DLPFC) of 24 ASD patients with normal or above average IQs and 18 matched control subjects. We hypothesized that we would find decreased GSH concentrations in both regions. Results: We did not find overall group differences in neurometabolites including GSH, neither in the dorsal ACC (Wilks' lambda test; p = 0.429) nor in the DLPFC (p = 0.288). In the dACC, we found a trend for decreased GSH signals in ASD patients (p = 0.076). Conclusions: We were unable to confirm our working hypothesis regarding decreased GSH concentrations in the ASD group. Further studies combining MRS, serum, and cerebrospinal fluid measurements of GSH metabolism including other regions of interest or even whole brain spectroscopy are needed.

引用

页数：11

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