RNA modifications and structures cooperate to guide RNA-protein interactions

被引：223

作者：

Lewis, Cole J. T. ^{[1
]}

Pan, Tao ^{[3
]}

Kalsotra, Auinash ^{[1
,2
]}

机构：

[1] Univ Illinois, Dept Biochem, Urbana, IL 61801 USA

[2] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA

[3] Univ Chicago, Dept Biochem & Mol Biol, 920 E 58Th St, Chicago, IL 60637 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2017年 / 18卷 / 03期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE MEASUREMENT; MESSENGER-RNA; SECONDARY STRUCTURE; SR PROTEINS; G-QUADRUPLEXES; NUCLEAR-RNA; BINDING PROTEIN; NONCODING RNAS; NASCENT RNA; HNRNP C;

D O I：

10.1038/nrm.2016.163

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An emerging body of evidence indicates that post-transcriptional gene regulation relies not only on the sequence of mRNAs but also on their folding into intricate secondary structures and on the chemical modifications of the RNA bases. These features, which are highly dynamic and interdependent, exert direct control over the transcriptome and thereby influence many aspects of cell function. Here, we consider how the coupling of RNA modifications and structures shapes RNA-protein interactions at different steps of the gene expression process.

引用

收藏

页码：202 / 210

页数：9

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