Enzymatic resolution of chroman-4-ol and its core analogues with Burkholderia cepacia lipase

被引：10

作者：

Kucher, Olexandr V. ^{[1
,2
]}

Kolodyazhnaya, Anastasiya O. ^{[1
,2
]}

Smolii, Oleg B. ^{[2
]}

Boiko, Alexandr I. ^{[1
,3
]}

Kubyshkin, Vladimir S. ^{[1
]}

Mykhailiuk, Pavel K. ^{[1
,4
]}

Tolmachev, Andrey A. ^{[1
,4
]}

机构：

[1] Enamine Ltd, UA-01103 Kiev, Ukraine

[2] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02094 Kiev, Ukraine

[3] Natl Tech Univ Ukraine, Kyiv Politech Inst, UA-03056 Kiev, Ukraine

[4] Taras Shevchenko Natl Univ Kyiv, Dept Chem, UA-01601 Kiev, Ukraine

来源：

TETRAHEDRON-ASYMMETRY | 2014年 / 25卷 / 6-7期

关键词：

DYNAMIC KINETIC RESOLUTION; SECONDARY ALCOHOLS; TRANSFER HYDROGENATION; FLAVONOIDS; ENANTIOMER; REDUCTION; COMPLEXES; ACYLATION; CATALYST; ENZYMES;

D O I：

10.1016/j.tetasy.2014.02.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A convenient protocol for lipase resolution of chroman-4-ol and its analogues (six- and seven-membered rings with O, S, SO2) has been elaborated. The structure of substrates has minor influence on the efficiency of resolution. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：563 / 567

页数：5

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