One-Pot Synthesis of 4H-Chromenes by Tandem Benzylation and Cyclization in the Presence of Sodium Bisulfate on Silica Gel

被引：17

作者：

Aoyama, Tadashi ^{[1
,2
]}

Yamamoto, Takumi ^{[1
]}

Miyota, Saki ^{[1
]}

Hayakawa, Mamiko ^{[1
]}

Takido, Toshio

Kodomari, Mitsuo ^{[3
]}

机构：

[1] Nihon Univ, Dept Mat & Appl Chem, Coll Sci & Technol, Chiyoda Ku, Tokyo 1018308, Japan

[2] Nihon Univ, Ctr Creat Mat Res, Res Inst Sci & Technol, Coll Sci & Technol,Chiyoda Ku, Tokyo 1018308, Japan

[3] Nihon Univ, Inst Nat Sci, Coll Humanities & Sci, Setagaya Ku, Tokyo 1568550, Japan

来源：

SYNLETT | 2014年 / 25卷 / 11期

关键词：

cyclizations; benzylations; supported reagents; chromenes; one-pot syntheses; FUNCTIONALIZED; 4H-CHROMENES; FACILE CONSTRUCTION; EFFICIENT; KETONES; 2H-CHROMENES; ANNULATION; CHROMENES; ALCOHOLS; PHENOLS;

D O I：

10.1055/s-0033-1339026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method has been developed for the synthesis of 4H-chromenes from o-hydroxybenzylic alcohols and dicarbonyl compounds containing active methylene groups by using silica gel supported sodium bisulfate. Various dicarbonyl compounds such as diketones, keto esters, and keto amides can be used in the synthesis of the 4H-chromenes.

引用

页码：1571 / 1576

页数：6

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