Detection of melamine by a magnetic relaxation switch assay with functionalized Fe/Fe3O4 nanoparticles

被引：26
作者：
Shen, Jinchao [1 ,2 ]
Zhang, Yang [1 ,2 ]
Yang, Hong [1 ,2 ]
Yang, Yan [1 ,2 ]
Zhou, Zhiguo [1 ,2 ]
Yang, Shiping [1 ,2 ,3 ]
机构：
[1] Shanghai Normal Univ, Key Lab Resource Chem, Shanghai Key Lab Rare Earth Funct Mat, Minist Educ, Shanghai 200234, Peoples R China
[2] Shanghai Normal Univ, Shanghai Municipal Educ Comm, Key Lab Mol Imaging Probes & Sensors, Shanghai 200234, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, People Hosp 3, Shanghai 201999, Peoples R China
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2014年 / 203卷
基金：
中国国家自然科学基金;
关键词：
Magnetic relaxation switch assay; Melamine; Fe/Fe3O4; nanoparticles; IRON-OXIDE NANOPARTICLES; RAW-MILK; GOLD NANOPARTICLES; CONTRAST AGENTS; MRI CONTRAST; MECHANISM; STRATEGY; SENSORS; SYSTEM;
D O I：
10.1016/j.snb.2014.07.026
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The detection for melamine has attracted much attention due to its toxicity to the kidney of animals and humans. Herein, we reported a magnetic relaxation switch (MRSw) assay for melamine with Fe/Fe3O4 nanoparticles functionalized by the dopamine conjugated with methoxypoly (ethylene glycol) carboxyl acid (mPEG-COOH) and (2,4,6-trioxo-1,3,5-triazin-1-yl) acetic acid (TTAA) (TTAA-Fe/Fe3O4 NPs). The approach of the MRSw assay for melamine is based on the aggregation of TTAA-Fe/Fe3O4 NPs induced by the special triple hydrogen bonds between melamine and TTAA, which results in the increase of the spin-spin relaxation time (T-2) of surrounding water protons of nanoparticles. Due to no limitation of light scattering, the detection of melamine with the MRSw assay can be performed in a turbid medium without pre-treatment and purification. Upon addition of the different concentration of melamine to an aqueous solution of TTAA-Fe/Fe3O4 NPs ( [Fe] = 32 mu M), the change of T-2 value has a good linear relationship with the concentration of melamine below 16 mu M. The limit of detection (LOD) for melamine is 2 mu M. Furthermore, the MRSw assay exhibits a high selectivity for melamine over cytosine, uracil and thymine with the similar structure. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：477 / 482
页数：6
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