The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation

被引:12
作者
Akama, Yuichi [1 ,2 ]
Satoh-Takayama, Naoko [3 ,4 ]
Kawamoto, Eiji [1 ,2 ]
Ito, Atsushi [1 ,5 ]
Gaowa, Arong [1 ]
Park, Eun Jeong [1 ]
Imai, Hiroshi [2 ]
Shimaoka, Motomu [1 ]
机构
[1] Mie Univ, Grad Sch Med, Dept Mol Pathobiol & Cell Adhes Biol, 2-174 Edobashi, Tsu, Mie 5148507, Japan
[2] Mie Univ, Grad Sch Med, Dept Emergency & Disaster Med, 2-174 Edobashi, Tsu, Mie 5148507, Japan
[3] RIKEN, Lab Intestinal Ecosyst, Ctr Integrat Med Sci, Tsurumi Ku, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan
[4] Yokohama City Univ, Grad Sch Med Life Sci, Immunobiol Lab, Tsurumi Ku, 1-7-29 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan
[5] Mie Univ, Grad Sch Med, Dept Thorac & Cardiovasc Surg, 2-174 Edobashi, Tsu, Mie 5148507, Japan
关键词
PD-1; group 2 innate lymphoid cells; sepsis; acute lung injury; IL-13; IL-33; ST2; natural and inflammatory ILC2; IL-33; PROMOTES; TYPE-2; IMMUNITY; INJURY; EXPRESSION; PD-1; PROTECTION; PROVIDE; IMMUNOSUPPRESSION; INTERLEUKIN-10; EPIDEMIOLOGY;
D O I
10.3390/diagnostics10100808
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Septic shock/severe sepsis is a deregulated host immune system response to infection that leads to life-threatening organ dysfunction. Lung inflammation as a form of acute lung injury (ALI) is often induced in septic shock. Whereas macrophages and neutrophils have been implicated as the principal immune cells regulating lung inflammation, group two innate lymphoid cells (ILC2s) have recently been identified as a new player regulating immune homeostasis. ILC2 is one of the three major ILC subsets (ILC1s, ILC2s, and ILC3s) comprised of newly identified innate immune cells. These cells are characterized by their ability to rapidly produce type 2 cytokines. ILC2s are predominant resident ILCs and, thereby, have the ability to respond to signals from damaged tissues. ILC2s regulate the immune response, and ILC2-derived type 2 cytokines may exert protective roles against sepsis-induced lung injury. This focused review not only provides readers with new insights into the signaling mechanisms by which ILC2s modulate sepsis-induced lung inflammation, but also proposes ILC2 as a novel therapeutic target for sepsis-induced ALI.
引用
收藏
页数:14
相关论文
共 50 条
  • [41] Innate lymphoid cells and fibrotic regulation
    Horsburgh, Steven
    Todryk, Stephen
    Ramming, Andreas
    Distler, Jorg H. W.
    O'Reilly, Steven
    IMMUNOLOGY LETTERS, 2018, 195 : 38 - 44
  • [42] Sepsis induced dysfunction of liver type 1 innate lymphoid cells
    Wang, Peiying
    Zheng, Yiran
    Sun, Jiaman
    Zhang, Yumo
    Chan, Wing Keung
    Lu, Yan
    Li, Xiaohong
    Yang, Zhouxin
    Wang, Youwei
    BMC IMMUNOLOGY, 2024, 25 (01)
  • [43] IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation
    Turner, Jan-Eric
    Morrison, Peter J.
    Wilhelm, Christoph
    Wilson, Mark
    Ahlfors, Helena
    Renauld, Jean-Christophe
    Panzer, Ulf
    Helmby, Helena
    Stockinger, Brigitta
    JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (13) : 2951 - 2965
  • [44] Chemokines and Innate Lymphoid Cells in Skin Inflammation
    Sun, Zhengwang
    Vattepu, Ravi
    Zhang, Songfa
    CELLS, 2021, 10 (11)
  • [45] Neural Regulation of Interactions Between Group 2 Innate Lymphoid Cells and Pulmonary Immune Cells
    Chen, Weiwei
    Shu, Qiang
    Fan, Jie
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [46] Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis
    Choi, Hee Sun
    Won, Taejoon
    Hou, Xuezhou
    Chen, Guobao
    Bracamonte-Baran, William
    Talor, Monica, V
    Jurcova, Ivana
    Szarszoi, Ondrej
    Curnova, Lenka
    Striz, Ilja
    Hooper, Jody E.
    Melenovsky, Vojtech
    Cihakova, Daniela
    CELL REPORTS, 2020, 30 (09): : 2989 - +
  • [47] Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
    Monticelli, Laurel A.
    Sonnenberg, Gregory F.
    Abt, Michael C.
    Alenghat, Theresa
    Ziegler, Carly G. K.
    Doering, Travis A.
    Angelosanto, Jill M.
    Laidlaw, Brian J.
    Yang, Cliff Y.
    Sathaliyawala, Taheri
    Kubota, Masaru
    Turner, Damian
    Diamond, Joshua M.
    Goldrath, Ananda W.
    Farber, Donna L.
    Collman, Ronald G.
    Wherry, E. John
    Artis, David
    NATURE IMMUNOLOGY, 2011, 12 (11) : 1045 - U47
  • [48] The role of type 2 innate lymphoid cells in asthma
    Chang, Ya-Jen
    DeKruyff, Rosemarie H.
    Umetsu, Dale T.
    JOURNAL OF LEUKOCYTE BIOLOGY, 2013, 94 (05) : 933 - 940
  • [49] Sepsis-mediated renal dysfunction: Pathophysiology, biomarkers and role of phytoconstituents in its management
    Balkrishna, Acharya
    Sinha, Sugandh
    Kumar, Ashwani
    Arya, Vedpriya
    Gautam, Ajay Kumar
    Valis, Martin
    Kuca, Kamil
    Kumar, Dinesh
    Amarowicz, Ryszard
    BIOMEDICINE & PHARMACOTHERAPY, 2023, 165
  • [50] A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut
    Teng, Fei
    Goc, Jeremy
    Zhou, Lei
    Chu, Coco
    Shah, Manish A.
    Eberl, Gerard
    Sonnenberg, Gregory F.
    SCIENCE IMMUNOLOGY, 2019, 4 (40)