The effect of estrogen in a man with Parkinson's disease and a review of its therapeutic potential

被引：9

作者：

Adams, Chris ^{[1
]}

Kumar, Rajeev ^{[1
]}

机构：

[1] Colorado Neurol Inst, Movement Disorders Ctr, Englewood, CO 80113 USA

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2013年 / 123卷 / 10期

关键词：

levodopa; dyskinesias; estrogen therapy; Parkinson's disease; transgender therapy; ESTRADIOL;

D O I：

10.3109/00207454.2013.797903

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Estrogen has been implicated in controlling the pathogenesis and symptoms of Parkinson's disease (PD) in women. Here, we report a 53-year-old male with PD who underwent estrogen therapy with estradiol (E2). Within a month, he exhibited increased dyskinesias. His medication was reduced by 35% from a levodopa equivalent dose (LED) of 820-535 over three months, which overall improved his motor fluctuations and dyskinesias. Therefore, E2 therapy could have therapeutic potential in males with PD.

引用

页码：741 / 742

页数：2

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