Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi

被引：41

作者：

Johnston, W. Thomas ^{[1
]}

Mutalima, Nora ^{[1
]}

Sun, David ^{[2
]}

Emmanuel, Benjamin ^{[3
]}

Bhatia, Kishor ^{[3
]}

Aka, Peter ^{[3
]}

Wu, Xiaolin ^{[2
]}

Borgstein, E. ^{[4
]}

Liomba, G. N. ^{[4
]}

Kamiza, Steve ^{[4
]}

Mkandawire, Nyengo ^{[4
]}

Batumba, Mkume ^{[4
]}

Carpenter, Lucy M. ^{[5
]}

Jaffe, Harold ^{[5
]}

Molyneux, Elizabeth M. ^{[4
]}

Goedert, James J. ^{[3
]}

Soppet, Daniel ^{[2
]}

Newton, Robert ^{[1
]}

Mbulaiteye, Sam M. ^{[3
]}

机构：

[1] Univ York, York YO10 5DD, N Yorkshire, England

[2] Frederick Natl Lab Canc Res, Frederick, MD USA

[3] Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[4] Queen Elizabeth Hosp, Blantyre, Malawi

[5] Univ Oxford, Oxford, England

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

关键词：

EPSTEIN-BARR-VIRUS; B-CELLS; ANTIBODIES; CHILDREN; IDENTIFICATION; COMPLEXITY; INFECTION; GENOTYPES; ANTIGEN;

D O I：

10.1038/srep03741

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Endemic Burkitt lymphoma (eBL) has been linked to Plasmodium falciparum (Pf) malaria infection, but the contribution of infection with multiple Pf genotypes is uncertain. We studied 303 eBL (cases) and 274 non eBL-related cancers (controls) in Malawi using a sensitive and specific molecular-barcode array of 24 independently segregating Pf single nucleotide polymorphisms. Cases had a higher Pf malaria prevalence than controls (64.7% versus 45.3%; odds ratio [OR] 2.1, 95% confidence interval (CI): 1.5 to 3.1). Cases and controls were similar in terms of Pf density (4.9 versus 4.5 log copies, p = 0.28) and having >= 3 non-clonal calls (OR 2.7, 95% CI: 0.7-9.9, P = 0.14). However, cases were more likely to have a higher Pf genetic diversity score (153.9 versus 133.1, p = 0.036), which measures a combination of clonal and non-clonal calls, than controls. Further work is needed to evaluate the possible role of Pf genetic diversity in the pathogenesis of endemic BL.

引用

页数：5

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