A novel three-component reaction for the synthesis of N-cyclohexyl-3-aryl-quinoxaline-2-amines

被引：92

作者：

Heravi, Majid M. ^{[1
]}

Baghernejad, Bita ^{[1
]}

Oskooie, Hossein A. ^{[1
]}

机构：

[1] Alzahra Univ, Sch Sci, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 07期

关键词：

O-Phenylenediamine; N-Cyclohexyl-3-aryl-quinoxaline-2-amines; Ferric perchlorate; Cyclohexyl isocyanide; Three-component reactions; SOLID-PHASE SYNTHESIS; MULTICOMPONENT REACTIONS; FERRIC PERCHLORATE; TETRAHYDROPYRANYL ETHERS; QUINOXALINE CHEMISTRY; THP ETHERS; CATALYST; ACETYLATION; COMPLEXES; CLEAVAGE;

D O I：

10.1016/j.tetlet.2008.11.123

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ferric perchlorate catalyzes the three-component condensation reaction of o-phenylenediamine, aromatic alclehydes, and cyclohexyl isocyanide to afford the corresponding N-cyclohexyl-3-aryl-quinoxaline-2-amines in good yields. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：767 / 769

页数：3

共 52 条

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Bailly C, 1999, ANTI-CANCER DRUG DES, V14, P291

[2]

Brown D J., 2004, The Chemistry of Heterocyclic Compounds

[3] Quinoxaline chemistry.: Part 13:: 3-carboxy-2-benzylamino substituted quinoxalines and N-[4-[(3-carboxyquinoxalin-2-yl) aminomethyl]benzoyl]-L-glutamates:: synthesis and evaluation of in vitro anticancer activity [J].