The Mechanisms of Type 2 Diabetes-Related White Matter Intensities: A Review

被引：24

作者：

Sun, Jing ^{[1
]}

Xu, Baofeng ^{[2
]}

Zhang, Xuejiao ^{[3
]}

He, Zhidong ^{[4
]}

Liu, Ziwei ^{[3
]}

Liu, Rui ^{[5
]}

Nan, Guangxian ^{[1
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Dept Neurol, Changchun, Peoples R China

[2] First Hosp Jilin Univ, Dept Neurosurg, Changchun, Peoples R China

[3] Jilin Univ, China Japan Union Hosp, Dept Endocrinol, Changchun, Peoples R China

[4] Jilin Univ, China Japan Union Hosp, Dept Neurosurg, Changchun, Peoples R China

[5] Jilin Univ, China Japan Union Hosp, Dept VIP Unit, Changchun, Peoples R China

来源：

FRONTIERS IN PUBLIC HEALTH | 2020年 / 8卷

基金：

中国国家自然科学基金;

关键词：

type 2 diabetes mellitus; white matter hyperintensities; mechanism; microvascular complication; review; SMALL-VESSEL DISEASE; OXIDATIVE STRESS; HOMOCYSTEINE METABOLISM; COGNITIVE IMPAIRMENT; INSULIN-RESISTANCE; BRAIN; RISK; PROGRESSION; MELLITUS; ATROPHY;

D O I：

10.3389/fpubh.2020.498056

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The continually increasing number of patients with type 2 diabetes is a worldwide health problem, and the incidence of microvascular complications is closely related to type 2 diabetes. Structural brain abnormalities are considered an important pathway through which type 2 diabetes causes brain diseases. In fact, there is considerable evidence that type 2 diabetes is associated with an increased risk of structural brain abnormalities such as lacunar infarcts (LIs), white matter hyperintensities (WMHs), and brain atrophy. WMHs are a common cerebral small-vessel disease in elderly adults, and it is characterized histologically by demyelination, loss of oligodendrocytes, and vacuolization as a result of small-vessel ischemia in the white matter. An increasing number of studies have found that diabetes is closely related to WMHs. However, the exact mechanism by which type 2 diabetes causes WMHs is not fully understood. This article reviews the mechanisms of type 2 diabetes-related WMHs to better understand the disease and provide help for better clinical treatment.

引用

页数：5

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