Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia

被引：16

作者：

Wootla, Bharath ^{[2
,3
,4
]}

Mahendra, Ankit ^{[2
,3
,4
]}

Dimitrov, Jordan D. ^{[2
,3
]}

Friboulet, Alain ^{[4
]}

Borel-Derlon, Annie ^{[5
]}

Rao, Desirazu N. ^{[6
]}

Uda, Taizo ^{[7
]}

Borg, Jeanne-Yvonne ^{[8
]}

Bayry, Jagadeesh ^{[2
,3
]}

Kaveri, Srinivas V. ^{[2
,3
]}

Lacroix-Desmazes, Sebastien ^{[1
,2
,3
]}

机构：

[1] Univ Paris 06, Equipe 16, UMR S 872, INSERM,Ctr Rech Cordeliers, F-75006 Paris, France

[2] Univ Paris 05, UMR S 872, F-75006 Paris, France

[3] INSERM, U872, F-75006 Paris, France

[4] Univ Technol Compiegne, CNRS, UMR Genie Enzymat & Cellulaire 6022, F-60205 Compiegne, France

[5] Univ Caen, Hematol Lab, EA 3212, F-14000 Caen, France

[6] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India

[7] Oita Univ, Fac Engn, Oita 8701192, Japan

[8] Rouen Univ Hosp, F-76031 Rouen, France

来源：

FEBS LETTERS | 2009年 / 583卷 / 15期

基金：

日本科学技术振兴机构;

关键词：

Catalytic antibody; Acquired hemophilia; Hemophilia A; FVIII inhibitor; Factor VIII; PFR-MCA; POLYREACTIVE CATALYTIC ANTIBODIES; TISSUE FACTOR EXPRESSION; INHIBITOR PATIENTS; SPECIFICITY; CHAIN;

D O I：

10.1016/j.febslet.2009.07.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anti-factor VIII (FVIII) inhibitory IgG may arise as alloantibodies to therapeutic FVIII in patients with congenital hemophilia A, or as autoantibodies to endogenous FVIII in individuals with acquired hemophilia. We have described FVIII-hydrolyzing IgG both in hemophilia A patients with anti-FVIII IgG and in acquired hemophilia patients. Here, we compared the properties of proteolytic auto- and allo-antibodies. Rates of FVIII hydrolysis differed significantly between the two groups of antibodies. Proline-phenylalanine-arginine-methylcoumarinamide was a surrogate substrate for FVIII-hydrolyzing autoantibodies. Our data suggest that populations of proteolytic anti-FVIII IgG in acquired hemophilia patients are different from that of inhibitor-positive hemophilia A patients. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2565 / 2572

页数：8

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