Redox-Neutral Couplings between Amides and Alkynes via Cobalt(III)-Catalyzed C-H Activation

被引：136

作者：

Kong, Lingheng ^{[1
]}

Yu, Songjie ^{[1
]}

Zhou, Xukai ^{[1
]}

Li, Xingwei ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 03期

关键词：

RUTHENIUM-CATALYZED CYCLIZATION; N-CARBAMOYL INDOLINES; REGIOSELECTIVE SYNTHESIS; INTERNAL ALKYNES; BOND FORMATION; ACCESS; ANNULATION; AMIDATION; ARYL; FUNCTIONALIZATION;

D O I：

10.1021/acs.orglett.5b03629

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-H activation assisted by a bifunctional directing group has allowed the construction of heterocycles. This is ideally catalyzed by earth-abundant and eco-friendly transition metals. We report Co(III)-catalyzed redox-neutral coupling between arenes and alkynes using an NH amide as an electrophilic directing group. The redox-neutral C-H activation/coupling afforded quinolines with water as the sole byproduct.

引用

页码：588 / 591

页数：4

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