Merkel cells and touch domes: more than mechanosensory functions?

被引：29
作者：
Xiao, Ying [1 ]
Williams, Jonathan S. [1 ]
Brownell, Isaac [1 ]
机构：
[1] NCI, Dermatol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
来源：
EXPERIMENTAL DERMATOLOGY | 2014年 / 23卷 / 10期
基金：
美国国家卫生研究院;
关键词：
endocrine; immune; mechanosensation; Merkel cell; touch dome; HAIR-FOLLICLES; CHROMOGRANIN-A; LANGERHANS CELLS; SKIN; CD200; PROLIFERATION; LOCALIZATION; VIP; COMPONENTS; RECEPTORS;
D O I：
10.1111/exd.12456
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The touch dome (TD) is an innervated structure in the epidermis of mammalian skin. Composed of specialized keratinocytes and neuroendocrine Merkel cells, the TD has distinct molecular characteristics compared to the surrounding epidermal keratinocytes. Much of the research on Merkel cell function has focused on their role in mechanosensation, specifically light touch. Recently, more has been discovered about Merkel cell molecular characteristics and their cells of origin. Here we review Merkel cell and TD biology, and discuss potential functions beyond mechanosensation.
引用
收藏
页码：692 / 695
页数：4
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