Aetiological overlap between obsessive-compulsive related and anxiety disorder symptoms: multivariate twin study

被引：30

作者：

Lopez-Sola, Clara ^{[1
,2
]}

Fontenelle, Leonardo F. ^{[3
,4
,5
]}

Bui, Minh ^{[6
]}

Hopper, John L. ^{[6
]}

Pantelis, Christos ^{[7
]}

Yuecel, Murat ^{[8
]}

Menchon, Jose M. ^{[1
,2
]}

Alonso, Pino ^{[1
,2
]}

Harrison, Ben J. ^{[7
]}

机构：

[1] Bellvitge Univ Hosp, Dept Psychiat, Bellvitge Biomed Res Inst IDIBELL, CIBERSAM G17, Barcelona, Spain

[2] Univ Barcelona, Dept Clin Sci, Bellvitge Campus, E-08007 Barcelona, Spain

[3] Univ Fed Rio de Janeiro, Inst Psiquiatna, Programa Transtornos Obsess Compuls & Ansiedade, Rio De Janeiro, Brazil

[4] Inst DOr Pesquisa & Ensino IDOR, Rio De Janeiro, Brazil

[5] Univ Fed Fluminense, Inst Saude Comunidade, Rio De Janeiro, Brazil

[6] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic 3053, Australia

[7] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne, Vic 3053, Australia

[8] Monash Univ, Sch Psychol & Psychiat, Monash Clin & Imaging Neurosci Lab, Clayton, Vic 3800, Australia

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2016年 / 208卷 / 01期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

ENVIRONMENTAL RISK-FACTORS; DIMENSIONAL REPRESENTATIONS; PSYCHOMETRIC PROPERTIES; SPECTRUM DISORDERS; OCD; SENSITIVITY; ASSOCIATIONS; SPECIFICITY; PREVALENCE; INVENTORY;

D O I：

10.1192/bjp.bp.114.156281

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background The aetiological boundary between obsessive-compulsive related disorders (OCRDs) including obsessive-compulsive disorder (OCD) and anxiety disorders is unclear and continues to generate debate. Aims To determine the genetic overlap and the pattern of causal relationships among OCRDs and anxiety disorders. Method Multivariate twin modelling methods and a new regression analysis to infer causation were used, involving 2495 male and female twins. Results The amount of common genetic liability observed for OCD symptoms was higher when considering anxiety disorders and OCRDs in the model V. modelling OCRD symptoms alone. OCD symptoms emerged as risk factors for the presence of generalised anxiety, panic and hoarding. symptoms, whereas social phobia appeared as a risk factor for OCD symptoms. Conclusions OCD represents a complex phenotype that includes important shared features with anxiety disorders and OCRDs. The novel patterns of risk identified between OCD and anxiety disorder may help to explain their frequent co-occurrence.

引用

页码：26 / 33

页数：8

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