S100 and impact of ECT on depression and cognition

被引:34
作者
Arts, Baer
Peters, Maarten
Ponds, Rudolf
Honig, Adriaan
Menheere, Paul
van Os, Jim
机构
[1] Maastricht Univ, EURON, Dept Psychiat & Neuropsychol, S Limburg Mental Hlth Res & Teaching Network, NL-6200 MD Maastricht, Netherlands
[2] Inst Psychiat, Div Psychol Med, London, England
[3] Maastricht Univ, Maastricht, Netherlands
[4] St Lucas Andreas Hosp, Dept Psychiat, Amsterdam, Netherlands
[5] Univ Hosp Maastricht, Dept Clin Chem, Maastricht, Netherlands
关键词
S100; ECT; cognition; depression; prospective;
D O I
10.1097/01.yct.0000235925.37494.2c
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Objectives: The main side effects of electroconvulsive therapy (ECT) are in the realm of cognition. The S100-beta is a calcium-binding protein that is expressed by astrocytes in the central nervous system during depression and has been suggested to modulate the impact of ECT on cognition. Methods: Serum samples of S100-beta were taken before and 1 and 3 hours after each ECT session in 12 depressed patients (mean age, 54 years), treated with bilateral ECT twice weekly (mean, 6 sessions). Measures of depression (Symptom Checklist-90 depression dimension) and a neurocognitive test battery yielding 3 domains of general cognition, memory, and subjective cognitive impairment were administered 1 day before and 5 and 30 days post-ECT. Results: Electroconvulsive therapy was associated with a reduction in depression and subjective cognitive impairment at 5 and 30 days post-ECT. Electroconvulsive therapy was associated with a small but significant rise in S100-beta 1 hour post-ECT (adjusted B = 0.013, P = 0.035), with a directionally similar but reduced effect size at 3 hours post-ECT (adjusted B = 0.010, P = 0.10). Higher level of S100-beta at baseline was associated with poorer memory function at 5 and 30 days of follow-up (adjusted B per tertile group increase, 0.38, P = 0.013) but also with less subjective cognitive impairment (B = -28.2, P < 0.001) and less depression at follow-up (B = -15, P = 0.009). Conclusion: The S100-beta at baseline may be a marker predicting and possibly mediating the differential impact of ECT on cognition and depression.
引用
收藏
页码:206 / 212
页数:7
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