Absolute configurations of N,N-dialkyl α-amino acids and β-amino alcohols from exciton-coupled circular dichroism spectra of Cu(II) complexes

被引：65

作者：

Zahn, S ^{[1
]}

Canary, JW ^{[1
]}

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 06期

关键词：

D O I：

10.1021/ol990715a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A circular dichroism technique has been applied to the absolute configurational assignment of acyclic alpha-amino acids and beta-amino alcohols with single stereogenic centers via a one-step derivitization procedure requiring microgram quantities of material. Metal ions fix the geometrical relationship of two chromophores, affording CD spectra that agree with theory on the basis of the expected conformation of the ligands in the metal complexes.

引用

页码：861 / 864

页数：4