Parallel Comparative Studies on Mouse Toxicity of Oxide Nanoparticle- and Gadolinium-Based T1 MRI Contrast Agents

被引：139

作者：

Chen, Rui ^{[1
]}

Ling, Daishun ^{[2
,3
,4
,5
]}

Zhao, Lin ^{[1
]}

Wang, Shuaifei ^{[2
]}

Liu, Ying ^{[1
]}

Bai, Ru ^{[1
]}

Baik, Seungmin ^{[4
,5
]}

Zhao, Yuliang ^{[1
]}

Chen, Chunying ^{[1
]}

Hyeon, Taeghwan ^{[4
,5
]}

机构：

[1] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[2] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China

[3] Zhejiang Univ, Minist Educ, Key Lab Biomed Engn, Hangzhou 310058, Zhejiang, Peoples R China

[4] Inst for Basic Sci Korea, Ctr Nanoparticle Res, Seoul 151742, South Korea

[5] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151742, South Korea

来源：

ACS NANO | 2015年 / 9卷 / 12期

基金：

中国国家自然科学基金;

关键词：

magnetic resonance imaging; contrast agent; iron oxide nanoparticles; toxicity evaluation; endoplasmic reticulum stress; biodistribution; ENDOPLASMIC-RETICULUM STRESS; XBP1; MESSENGER-RNA; MAGNETIC NANOPARTICLES; CORONA; CELL; T-1; GD; NANOCRYSTALS; 21ST-CENTURY; RELAXIVITY;

D O I：

10.1021/acsnano.5b05783

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnetic resonance imaging (MRI) contrast agents with high relaxivity are highly desirable because they can significantly increase the accuracy of diagnosis. However, they can be potentially toxic to the patients. In this study, using a mouse model, we investigate the toxic effects and subsequent tissue damage induced by three T1 MRI contrast agents: gadopentetate dimeglumine injection (01), a clinically used gadolinium (Gd)-based contrast agent (GBCAs), and oxide nanoparticle (NP)-based contrast agents, extremely small-sized iron oxide NPs (ESIONs) and manganese oxide (MnO) NPs. Biodistribution, hematological and histopathological changes, inflammation, and the endoplasmic reticulum (ER) stress responses are evaluated for 24 h after intravenous injection. These thorough assessments of the toxic and stress responses of these agents provide a panoramic description of safety concerns and underlying mechanisms of the toxicity of contrast agents in the body. We demonstrate that ESIONs exhibit fewer adverse effects than the MnO NPs and the clinically used GDI GBCAs, providing useful information on future applications of ESIONs as potentially safe MRI contrast agents.

引用

页码：12425 / 12435

页数：11

共 65 条

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