Role of Uremic Toxins for Kidney, Cardiovascular, and Bone Dysfunction

被引：100

作者：

Fujii, Hideki ^{[1
,2
]}

Goto, Shunsuke ^{[1
,2
]}

Fukagawa, Masafumi ^{[3
]}

机构：

[1] Kobe Univ, Grad Sch Med, Div Nephrol, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ, Grad Sch Med, Kidney Ctr, Kobe, Hyogo 6500017, Japan

[3] Tokai Univ, Div Nephrol Endocrinol & Metab, Sch Med, Isehara, Kanagawa 2591193, Japan

来源：

TOXINS | 2018年 / 10卷 / 05期

关键词：

uremic toxins; chronic kidney disease; cardiovascular disease; bone disease; indoxyl sulfate; asymmetric dimethylarginine; p-cresylsulfate; P-CRESYL SULFATE; NITRIC-OXIDE SYNTHASE; ASYMMETRIC DIMETHYLARGININE ADMA; ENDOTHELIAL PROGENITOR CELLS; OSTEOBLAST-SPECIFIC PROTEINS; ORGANIC ANION TRANSPORTERS; CHARCOAL ADSORBENT AST-120; RENIN-ANGIOTENSIN SYSTEM; LOW-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS;

D O I：

10.3390/toxins10050202

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

With decreasing kidney function, cardiovascular disease (CVD) and mineral bone disorders frequently emerge in patients with chronic kidney disease (CKD). For these patients, in addition to the traditional risk factors, non-traditional CKD-specific risk factors are also associated with such diseases and conditions. One of these non-traditional risk factors is the accumulation of uremic toxins (UTs). In addition, the accumulation of UTs further deteriorates kidney function. Recently, a huge number of UTs have been identified. Although many experimental and clinical studies have reported associations between UTs and the progression of CKD, CVD, and bone disease, these relationships are very complex and have not been fully elucidated. Among the UTs, indoxyl sulfate, asymmetric dimethylarginine, and p-cresylsulfate have been of particular focus, up until now. In this review, we summarize the pathophysiological influences of these UTs on the kidney, cardiovascular system, and bone, and discuss the clinical data regarding the harmful effects of these UTs on diseases and conditions.

引用

页数：18

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