External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data From 140 US Hospitals

被引：51

作者：

Kadri, Sameer S. ^{[1
]}

Lai, Yi Ling ^{[2
]}

Ricotta, Emily E. ^{[2
]}

Strich, Jeffrey R. ^{[1
,3
]}

Babiker, Ahmed ^{[4
]}

Rhee, Chanu ^{[5
,6
,7
]}

Klompas, Michael ^{[5
,6
,7
]}

Dekker, John P. ^{[8
]}

Powers, John H., III ^{[9
]}

Danner, Robert L. ^{[1
]}

Adjemian, Jennifer ^{[2
,3
]}

机构：

[1] NIH, Dept Crit Care Med, Clin Ctr, 10 Ctr Dr B10,2C145, Bethesda, MD 20892 USA

[2] NIAID, Epidemiol Unit, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[3] US PHS, Commissioned Corps, Rockville, MD USA

[4] Univ Pittsburgh, Med Ctr, Div Infect Dis, Pittsburgh, PA USA

[5] Brigham & Womens Hosp, Div Infect Dis, 75 Francis St, Boston, MA 02115 USA

[6] Harvard Med Sch, Dept Populat Med, Boston, MA 02115 USA

[7] Harvard Pilgrim Hlth Care Inst, Boston, MA USA

[8] NIAID, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[9] NCI, Clin Res Directorate, Clin Monitoring Res Program, Frederick Natl Lab Canc Res, Bethesda, MD 20892 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2019年 / 6卷 / 04期

基金：

美国国家卫生研究院; 美国医疗保健研究与质量局;

关键词：

antimicrobial resistance; gram-negative bacteria; mortality; SEPSIS; OUTCOMES;

D O I：

10.1093/ofid/ofz110

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Difficult-to-treat resistance (DTR; ie, co-resistance to all first-line antibiotics) in gram-negative bloodstream infection (GNBSI) is associated with decreased survival in administrative data models. We externally validated DTR prevalence and associated mortality risk in GNBSI using detailed clinical data from electronic health records to adjust for baseline differences in acute illness severity.

引用

页数：4

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